ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

P2X purinoceptor 4

Intramolecular
Cysteine 132 and cysteine 159
Cysteine 126 and cysteine 149
Cysteine 116 and cysteine 165
Cysteine 126 and cysteine 159
Cysteine 126 and cysteine 132
Cysteine 149 and cysteine 159
Cysteine 132 and cysteine 149
A redox-regulated disulphide may form within P2X purinoceptor 4 between cysteines 132 and 159.

Details

Redox score ?
86
PDB code
2rup
Structure name
solution structure of rat p2x4 receptor head domain
Structure deposition date
2014-11-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51577
Residue number A
132
Residue number B
159
Peptide name
P2X purinoceptor 4

Ligandability

Cysteine 132 of P2X purinoceptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 159 of P2X purinoceptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within P2X purinoceptor 4 between cysteines 126 and 149.

Details

Redox score ?
86
PDB code
2rup
Structure name
solution structure of rat p2x4 receptor head domain
Structure deposition date
2014-11-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51577
Residue number A
126
Residue number B
149
Peptide name
P2X purinoceptor 4

Ligandability

Cysteine 126 of P2X purinoceptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of P2X purinoceptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within P2X purinoceptor 4 between cysteines 116 and 165.

Details

Redox score ?
85
PDB code
2rup
Structure name
solution structure of rat p2x4 receptor head domain
Structure deposition date
2014-11-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51577
Residue number A
116
Residue number B
165
Peptide name
P2X purinoceptor 4

Ligandability

Cysteine 116 of P2X purinoceptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 165 of P2X purinoceptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within P2X purinoceptor 4 between cysteines 126 and 159.

Details

Redox score ?
80
PDB code
2rup
Structure name
solution structure of rat p2x4 receptor head domain
Structure deposition date
2014-11-12
Thiol separation (Å)
3
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51577
Residue number A
126
Residue number B
159
Peptide name
P2X purinoceptor 4

Ligandability

Cysteine 126 of P2X purinoceptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 159 of P2X purinoceptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within P2X purinoceptor 4 between cysteines 126 and 132.

Details

Redox score ?
79
PDB code
2rup
Structure name
solution structure of rat p2x4 receptor head domain
Structure deposition date
2014-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51577
Residue number A
126
Residue number B
132
Peptide name
P2X purinoceptor 4

Ligandability

Cysteine 126 of P2X purinoceptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 of P2X purinoceptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within P2X purinoceptor 4 between cysteines 149 and 159.

Details

Redox score ?
73
PDB code
2rup
Structure name
solution structure of rat p2x4 receptor head domain
Structure deposition date
2014-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51577
Residue number A
149
Residue number B
159
Peptide name
P2X purinoceptor 4

Ligandability

Cysteine 149 of P2X purinoceptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 159 of P2X purinoceptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within P2X purinoceptor 4 between cysteines 132 and 149.

Details

Redox score ?
71
PDB code
2rup
Structure name
solution structure of rat p2x4 receptor head domain
Structure deposition date
2014-11-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51577
Residue number A
132
Residue number B
149
Peptide name
P2X purinoceptor 4

Ligandability

Cysteine 132 of P2X purinoceptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of P2X purinoceptor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: