P2X purinoceptor 7
Intermolecular
Cysteine 362 and cysteine 4
Cysteine 363 and cysteine 4
Intramolecular
Cysteine 260 and cysteine 269
Cysteine 216 and cysteine 226
Cysteine 477 and cysteine 498
Cysteine 482 and cysteine 498
Cysteine 477 and cysteine 482
Cysteine 479 and cysteine 498
Cysteine 119 and cysteine 168
Cysteine 371 and cysteine 374
More...Cysteine 373 and cysteine 374
Cysteine 129 and cysteine 152
Cysteine 362 and cysteine 363
Cysteine 498 and cysteine 499
Cysteine 477 and cysteine 479
Cysteine 135 and cysteine 152
Cysteine 129 and cysteine 135
Cysteine 479 and cysteine 572
Cysteine 371 and cysteine 373
Cysteine 498 and cysteine 572
Cysteine 374 and cysteine 377
Cysteine 4 and cysteine 5
Cysteine 479 and cysteine 506
Cysteine 506 and cysteine 572
Cysteine 498 and cysteine 506
Cysteine 499 and cysteine 506
Cysteine 129 and cysteine 162
Cysteine 135 and cysteine 162
Cysteine 477 and cysteine 572
Cysteine 152 and cysteine 162
Cysteine 477 and cysteine 499
Cysteine 572 and cysteine 573
Cysteine 477 and cysteine 506
Cysteine 373 and cysteine 377
Cysteine 363 and cysteine 374
Cysteine 506 and cysteine 573
Cysteine 482 and cysteine 506
Cysteine 363 and cysteine 371
Cysteine 498 and cysteine 573
Cysteine 479 and cysteine 482
6u9v B 362 C 4
A redox-regulated disulphide may form between two units of P2X purinoceptor 7 at cysteines 362 and 4.
Details
Redox score ?
69
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
nan
Peptide A name
P2X purinoceptor 7
Peptide B name
P2X purinoceptor 7
Peptide A accession
Q64663
Peptide B accession
Q64663
Peptide A residue number
362
Peptide B residue number
4
Ligandability
Cysteine 362 of P2X purinoceptor 7
Cysteine 4 of P2X purinoceptor 7
6u9v A 363 B 4
A redox-regulated disulphide may form between two units of P2X purinoceptor 7 at cysteines 363 and 4. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
12
% buried
nan
Peptide A name
P2X purinoceptor 7
Peptide B name
P2X purinoceptor 7
Peptide A accession
Q64663
Peptide B accession
Q64663
Peptide A residue number
363
Peptide B residue number
4
Ligandability
Cysteine 363 of P2X purinoceptor 7
Cysteine 4 of P2X purinoceptor 7
6u9v A 260 A 269
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 260 and 269.
Details
Redox score ?
86
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q64663
Residue number A
260
Residue number B
269
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 260 of P2X purinoceptor 7
Cysteine 269 of P2X purinoceptor 7
6u9v B 216 B 226
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 216 and 226.
Details
Redox score ?
85
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q64663
Residue number A
216
Residue number B
226
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 216 of P2X purinoceptor 7
Cysteine 226 of P2X purinoceptor 7
6u9v C 477 C 498
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 477 and 498.
Details
Redox score ?
84
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
3
% buried
50
Peptide accession
Q64663
Residue number A
477
Residue number B
498
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 477 of P2X purinoceptor 7
Cysteine 498 of P2X purinoceptor 7
6u9v C 482 C 498
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 482 and 498.
Details
Redox score ?
83
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
3
% buried
66
Peptide accession
Q64663
Residue number A
482
Residue number B
498
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 482 of P2X purinoceptor 7
Cysteine 498 of P2X purinoceptor 7
6u9w A 477 A 482
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 477 and 482.
Details
Redox score ?
81
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
8
% buried
39
Peptide accession
Q64663
Residue number A
477
Residue number B
482
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 477 of P2X purinoceptor 7
Cysteine 482 of P2X purinoceptor 7
6u9w B 479 B 498
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 479 and 498.
Details
Redox score ?
81
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
4
% buried
nan
Peptide accession
Q64663
Residue number A
479
Residue number B
498
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 479 of P2X purinoceptor 7
Cysteine 498 of P2X purinoceptor 7
6u9w C 119 C 168
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 119 and 168.
Details
Redox score ?
81
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q64663
Residue number A
119
Residue number B
168
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 119 of P2X purinoceptor 7
Cysteine 168 of P2X purinoceptor 7
6u9w B 371 B 374
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 371 and 374.
Details
Redox score ?
80
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
30
Minimum pKa ?
8
% buried
0
Peptide accession
Q64663
Residue number A
371
Residue number B
374
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 371 of P2X purinoceptor 7
Cysteine 374 of P2X purinoceptor 7
6u9v C 373 C 374
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 373 and 374.
Details
Redox score ?
80
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
30
Minimum pKa ?
9
% buried
0
Peptide accession
Q64663
Residue number A
373
Residue number B
374
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 373 of P2X purinoceptor 7
Cysteine 374 of P2X purinoceptor 7
6u9v A 129 A 152
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 129 and 152.
Details
Redox score ?
79
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
0
Peptide accession
Q64663
Residue number A
129
Residue number B
152
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 129 of P2X purinoceptor 7
Cysteine 152 of P2X purinoceptor 7
6u9w A 362 A 363
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 362 and 363.
Details
Redox score ?
77
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
2
Peptide accession
Q64663
Residue number A
362
Residue number B
363
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 362 of P2X purinoceptor 7
Cysteine 363 of P2X purinoceptor 7
6u9w A 498 A 499
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 498 and 499.
Details
Redox score ?
76
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
4
% buried
62
Peptide accession
Q64663
Residue number A
498
Residue number B
499
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 498 of P2X purinoceptor 7
Cysteine 499 of P2X purinoceptor 7
6u9v A 477 A 479
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 477 and 479.
Details
Redox score ?
74
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
nan
Peptide accession
Q64663
Residue number A
477
Residue number B
479
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 477 of P2X purinoceptor 7
Cysteine 479 of P2X purinoceptor 7
6u9v C 135 C 152
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 135 and 152.
Details
Redox score ?
73
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
nan
Peptide accession
Q64663
Residue number A
135
Residue number B
152
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 135 of P2X purinoceptor 7
Cysteine 152 of P2X purinoceptor 7
6u9w B 129 B 135
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 129 and 135.
Details
Redox score ?
72
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
6
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
0
Peptide accession
Q64663
Residue number A
129
Residue number B
135
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 129 of P2X purinoceptor 7
Cysteine 135 of P2X purinoceptor 7
6u9v B 479 B 572
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 479 and 572.
Details
Redox score ?
72
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q64663
Residue number A
479
Residue number B
572
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 479 of P2X purinoceptor 7
Cysteine 572 of P2X purinoceptor 7
6u9v A 371 A 373
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 371 and 373.
Details
Redox score ?
72
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
5
Half-sphere exposure sum ?
27
Minimum pKa ?
9
% buried
0
Peptide accession
Q64663
Residue number A
371
Residue number B
373
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 371 of P2X purinoceptor 7
Cysteine 373 of P2X purinoceptor 7
6u9w A 498 A 572
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 498 and 572.
Details
Redox score ?
69
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
4
% buried
nan
Peptide accession
Q64663
Residue number A
498
Residue number B
572
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 498 of P2X purinoceptor 7
Cysteine 572 of P2X purinoceptor 7
6u9v C 374 C 377
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 374 and 377.
Details
Redox score ?
69
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
5
Half-sphere exposure sum ?
45
Minimum pKa ?
11
% buried
22
Peptide accession
Q64663
Residue number A
374
Residue number B
377
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 374 of P2X purinoceptor 7
Cysteine 377 of P2X purinoceptor 7
6u9v A 4 A 5
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 4 and 5.
Details
Redox score ?
67
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
nan
Peptide accession
Q64663
Residue number A
4
Residue number B
5
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 4 of P2X purinoceptor 7
Cysteine 5 of P2X purinoceptor 7
6u9v A 479 A 506
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 479 and 506.
Details
Redox score ?
66
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
13
% buried
nan
Peptide accession
Q64663
Residue number A
479
Residue number B
506
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 479 of P2X purinoceptor 7
Cysteine 506 of P2X purinoceptor 7
6u9w A 506 A 572
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 506 and 572.
Details
Redox score ?
65
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
13
% buried
nan
Peptide accession
Q64663
Residue number A
506
Residue number B
572
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 506 of P2X purinoceptor 7
Cysteine 572 of P2X purinoceptor 7
6u9w C 498 C 506
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 498 and 506.
Details
Redox score ?
64
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
4
% buried
52
Peptide accession
Q64663
Residue number A
498
Residue number B
506
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 498 of P2X purinoceptor 7
Cysteine 506 of P2X purinoceptor 7
6u9w B 499 B 506
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 499 and 506.
Details
Redox score ?
64
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
13
% buried
64
Peptide accession
Q64663
Residue number A
499
Residue number B
506
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 499 of P2X purinoceptor 7
Cysteine 506 of P2X purinoceptor 7
6u9w C 129 C 162
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 129 and 162.
Details
Redox score ?
61
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
8
% buried
22
Peptide accession
Q64663
Residue number A
129
Residue number B
162
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 129 of P2X purinoceptor 7
Cysteine 162 of P2X purinoceptor 7
6u9w A 135 A 162
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 135 and 162. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
22
Peptide accession
Q64663
Residue number A
135
Residue number B
162
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 135 of P2X purinoceptor 7
Cysteine 162 of P2X purinoceptor 7
6u9w C 477 C 572
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 477 and 572. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
63
Minimum pKa ?
8
% buried
nan
Peptide accession
Q64663
Residue number A
477
Residue number B
572
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 477 of P2X purinoceptor 7
Cysteine 572 of P2X purinoceptor 7
6u9w B 152 B 162
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 152 and 162. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
22
Peptide accession
Q64663
Residue number A
152
Residue number B
162
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 152 of P2X purinoceptor 7
Cysteine 162 of P2X purinoceptor 7
6u9v A 477 A 499
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 477 and 499. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
56
Peptide accession
Q64663
Residue number A
477
Residue number B
499
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 477 of P2X purinoceptor 7
Cysteine 499 of P2X purinoceptor 7
6u9v B 572 B 573
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 572 and 573. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
17
% buried
nan
Peptide accession
Q64663
Residue number A
572
Residue number B
573
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 572 of P2X purinoceptor 7
Cysteine 573 of P2X purinoceptor 7
6u9v B 477 B 506
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 477 and 506. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
46
Peptide accession
Q64663
Residue number A
477
Residue number B
506
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 477 of P2X purinoceptor 7
Cysteine 506 of P2X purinoceptor 7
6u9w A 373 A 377
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 373 and 377. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
39
Minimum pKa ?
9
% buried
18
Peptide accession
Q64663
Residue number A
373
Residue number B
377
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 373 of P2X purinoceptor 7
Cysteine 377 of P2X purinoceptor 7
6u9w C 363 C 374
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 363 and 374. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
41
Minimum pKa ?
10
% buried
1
Peptide accession
Q64663
Residue number A
363
Residue number B
374
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 363 of P2X purinoceptor 7
Cysteine 374 of P2X purinoceptor 7
6u9v B 506 B 573
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 506 and 573. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
13
% buried
80
Peptide accession
Q64663
Residue number A
506
Residue number B
573
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 506 of P2X purinoceptor 7
Cysteine 573 of P2X purinoceptor 7
6u9w A 482 A 506
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 482 and 506. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
13
% buried
55
Peptide accession
Q64663
Residue number A
482
Residue number B
506
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 482 of P2X purinoceptor 7
Cysteine 506 of P2X purinoceptor 7
6u9v A 363 A 371
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 363 and 371. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
41
Minimum pKa ?
10
% buried
14
Peptide accession
Q64663
Residue number A
363
Residue number B
371
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 363 of P2X purinoceptor 7
Cysteine 371 of P2X purinoceptor 7
6u9w A 498 A 573
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 498 and 573. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6u9w
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the atp-bound, open state
Structure deposition date
2019-09-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
4
% buried
75
Peptide accession
Q64663
Residue number A
498
Residue number B
573
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 498 of P2X purinoceptor 7
Cysteine 573 of P2X purinoceptor 7
6u9v A 479 A 482
A redox-regulated disulphide may form within P2X purinoceptor 7 between cysteines 479 and 482. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6u9v
Structure name
cryo electron microscopy structure of the atp-gated rat p2x7 ion channel in the apo, closed state
Structure deposition date
2019-09-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
24
% buried
nan
Peptide accession
Q64663
Residue number A
479
Residue number B
482
Peptide name
P2X purinoceptor 7
Ligandability
Cysteine 479 of P2X purinoceptor 7
Cysteine 482 of P2X purinoceptor 7
If this tool was useful for finding a disulphide, please cite: