ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ribonucleases P/MRP protein subunit POP1

Intramolecular
Cysteine 876 and cysteine 959
Cysteine 705 and cysteine 706
Cysteine 251 and cysteine 252
Cysteine 347 and cysteine 349
Cysteine 481 and cysteine 548
Cysteine 252 and cysteine 559
A redox-regulated disulphide may form within Ribonucleases P/MRP protein subunit POP1 between cysteines 876 and 959.

Details

Redox score ?
65
PDB code
6ahr
Structure name
cryo-em structure of human ribonuclease p
Structure deposition date
2018-08-20
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
77
Peptide accession
Q99575
Residue number A
876
Residue number B
959
Peptide name
Ribonucleases P/MRP protein subunit POP1

Ligandability

Cysteine 876 of Ribonucleases P/MRP protein subunit POP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 959 of Ribonucleases P/MRP protein subunit POP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonucleases P/MRP protein subunit POP1 between cysteines 705 and 706. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6ahr
Structure name
cryo-em structure of human ribonuclease p
Structure deposition date
2018-08-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
58
Peptide accession
Q99575
Residue number A
705
Residue number B
706
Peptide name
Ribonucleases P/MRP protein subunit POP1

Ligandability

Cysteine 705 of Ribonucleases P/MRP protein subunit POP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 706 of Ribonucleases P/MRP protein subunit POP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonucleases P/MRP protein subunit POP1 between cysteines 251 and 252. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6ahr
Structure name
cryo-em structure of human ribonuclease p
Structure deposition date
2018-08-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
92
Peptide accession
Q99575
Residue number A
251
Residue number B
252
Peptide name
Ribonucleases P/MRP protein subunit POP1

Ligandability

Cysteine 251 of Ribonucleases P/MRP protein subunit POP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 252 of Ribonucleases P/MRP protein subunit POP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonucleases P/MRP protein subunit POP1 between cysteines 347 and 349. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6ahu
Structure name
cryo-em structure of human ribonuclease p with mature trna
Structure deposition date
2018-08-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
31
Peptide accession
Q99575
Residue number A
347
Residue number B
349
Peptide name
Ribonucleases P/MRP protein subunit POP1

Ligandability

Cysteine 347 of Ribonucleases P/MRP protein subunit POP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 349 of Ribonucleases P/MRP protein subunit POP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonucleases P/MRP protein subunit POP1 between cysteines 481 and 548. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6ahu
Structure name
cryo-em structure of human ribonuclease p with mature trna
Structure deposition date
2018-08-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
24
Peptide accession
Q99575
Residue number A
481
Residue number B
548
Peptide name
Ribonucleases P/MRP protein subunit POP1

Ligandability

Cysteine 481 of Ribonucleases P/MRP protein subunit POP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 548 of Ribonucleases P/MRP protein subunit POP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonucleases P/MRP protein subunit POP1 between cysteines 252 and 559. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6ahu
Structure name
cryo-em structure of human ribonuclease p with mature trna
Structure deposition date
2018-08-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
86
Peptide accession
Q99575
Residue number A
252
Residue number B
559
Peptide name
Ribonucleases P/MRP protein subunit POP1

Ligandability

Cysteine 252 of Ribonucleases P/MRP protein subunit POP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 559 of Ribonucleases P/MRP protein subunit POP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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