ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

SPRY domain-containing SOCS box protein 2

Intramolecular
Cysteine 65 and cysteine 210
A redox-regulated disulphide may form within SPRY domain-containing SOCS box protein 2 between cysteines 65 and 210. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
3ek9
Structure name
spry domain-containing socs box protein 2: crystal structure and residues critical for protein binding
Structure deposition date
2008-09-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
67
Peptide accession
O88838
Residue number A
65
Residue number B
210
Peptide name
SPRY domain-containing SOCS box protein 2

Ligandability

Cysteine 65 of SPRY domain-containing SOCS box protein 2

Cysteine 210 of SPRY domain-containing SOCS box protein 2

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