ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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COP9 signalosome complex subunit 8

Intermolecular
Cysteine 154 of COP9 signalosome complex subunit 3 and cysteine 20
A redox-regulated disulphide may form between cysteine 154 of COP9 signalosome complex subunit 3 and cysteine 20 of COP9 signalosome complex subunit 8. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
6r7f
Structure name
structural basis of cullin-2 ring e3 ligase regulation by the cop9 signalosome
Structure deposition date
2019-03-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
82
Peptide A name
COP9 signalosome complex subunit 3
Peptide B name
COP9 signalosome complex subunit 8
Peptide A accession
Q9UNS2
Peptide B accession
Q99627
Peptide A residue number
154
Peptide B residue number
20

Ligandability

Cysteine 154 of COP9 signalosome complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 20 of COP9 signalosome complex subunit 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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