Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Intramolecular
Cysteine 169 and cysteine 170
Cysteine 169 and cysteine 247
Cysteine 190 and cysteine 247
Cysteine 198 and cysteine 247
5vcz A 169 A 170
A redox-regulated disulphide may form within Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase between cysteines 169 and 170. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
5vcz
Structure name
crystal structure of human myt1 kinase domain in complex with bosutinib isomer
Structure deposition date
2017-04-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
69
Peptide accession
Q99640
Residue number A
169
Residue number B
170
Peptide name
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Ligandability
Cysteine 169 of Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Cysteine 170 of Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
5vd3 A 169 A 247
A redox-regulated disulphide may form within Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase between cysteines 169 and 247. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
5vd3
Structure name
crystal structure of human myt1 kinase domain (de-phosphorylated) in complex with saracatinib
Structure deposition date
2017-04-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
68
Peptide accession
Q99640
Residue number A
169
Residue number B
247
Peptide name
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Ligandability
Cysteine 169 of Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Cysteine 247 of Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
5vcz A 190 A 247
A redox-regulated disulphide may form within Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase between cysteines 190 and 247. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
5vcz
Structure name
crystal structure of human myt1 kinase domain in complex with bosutinib isomer
Structure deposition date
2017-04-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
92
Peptide accession
Q99640
Residue number A
190
Residue number B
247
Peptide name
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Ligandability
Cysteine 190 of Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Cysteine 247 of Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
5vd3 A 198 A 247
A redox-regulated disulphide may form within Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase between cysteines 198 and 247. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
5vd3
Structure name
crystal structure of human myt1 kinase domain (de-phosphorylated) in complex with saracatinib
Structure deposition date
2017-04-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
75
Peptide accession
Q99640
Residue number A
198
Residue number B
247
Peptide name
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Ligandability
Cysteine 198 of Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Cysteine 247 of Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
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