Kinesin-like protein KIF2C
Intramolecular
Cysteine 245 and cysteine 310
Cysteine 287 and cysteine 310
Cysteine 260 and cysteine 262
Cysteine 260 and cysteine 560
Cysteine 344 and cysteine 560
Cysteine 245 and cysteine 287
Cysteine 262 and cysteine 560
Cysteine 260 and cysteine 344
Cysteine 258 and cysteine 340
Cysteine 241 and cysteine 256
More...Cysteine 241 and cysteine 258
Cysteine 256 and cysteine 283
Cysteine 258 and cysteine 283
5mio C 245 C 310
A redox-regulated disulphide may form within Kinesin-like protein KIF2C between cysteines 245 and 310.
Details
Redox score ?
73
PDB code
5mio
Structure name
kif2c-darpin fusion protein bound to tubulin
Structure deposition date
2016-11-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
20
Peptide accession
Q99661
Residue number A
245
Residue number B
310
Peptide name
Kinesin-like protein KIF2C
Ligandability
Cysteine 245 of Kinesin-like protein KIF2C
Cysteine 310 of Kinesin-like protein KIF2C
4ubf A 287 A 310
A redox-regulated disulphide may form within Kinesin-like protein KIF2C between cysteines 287 and 310.
Details
Redox score ?
69
PDB code
4ubf
Structure name
hsmcak motor domain complex
Structure deposition date
2014-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
6
% buried
91
Peptide accession
Q99661
Residue number A
287
Residue number B
310
Peptide name
Kinesin-like protein KIF2C
Ligandability
Cysteine 287 of Kinesin-like protein KIF2C
Cysteine 310 of Kinesin-like protein KIF2C
2heh A 260 A 262
A redox-regulated disulphide may form within Kinesin-like protein KIF2C between cysteines 260 and 262.
Details
Redox score ?
68
PDB code
2heh
Structure name
crystal structure of the kif2c motor domain
Structure deposition date
2006-06-21
Thiol separation (Å)
3
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99661
Residue number A
260
Residue number B
262
Peptide name
Kinesin-like protein KIF2C
Ligandability
Cysteine 260 of Kinesin-like protein KIF2C
Cysteine 262 of Kinesin-like protein KIF2C
4ubf D 260 D 560
A redox-regulated disulphide may form within Kinesin-like protein KIF2C between cysteines 260 and 560.
Details
Redox score ?
66
PDB code
4ubf
Structure name
hsmcak motor domain complex
Structure deposition date
2014-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
9
% buried
100
Peptide accession
Q99661
Residue number A
260
Residue number B
560
Peptide name
Kinesin-like protein KIF2C
Ligandability
Cysteine 260 of Kinesin-like protein KIF2C
Cysteine 560 of Kinesin-like protein KIF2C
4ubf D 344 D 560
A redox-regulated disulphide may form within Kinesin-like protein KIF2C between cysteines 344 and 560.
Details
Redox score ?
65
PDB code
4ubf
Structure name
hsmcak motor domain complex
Structure deposition date
2014-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
90
Minimum pKa ?
9
% buried
100
Peptide accession
Q99661
Residue number A
344
Residue number B
560
Peptide name
Kinesin-like protein KIF2C
Ligandability
Cysteine 344 of Kinesin-like protein KIF2C
Cysteine 560 of Kinesin-like protein KIF2C
5mio C 245 C 287
A redox-regulated disulphide may form within Kinesin-like protein KIF2C between cysteines 245 and 287.
Details
Redox score ?
60
PDB code
5mio
Structure name
kif2c-darpin fusion protein bound to tubulin
Structure deposition date
2016-11-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
48
Minimum pKa ?
8
% buried
8
Peptide accession
Q99661
Residue number A
245
Residue number B
287
Peptide name
Kinesin-like protein KIF2C
Ligandability
Cysteine 245 of Kinesin-like protein KIF2C
Cysteine 287 of Kinesin-like protein KIF2C
5mio C 262 C 560
A redox-regulated disulphide may form within Kinesin-like protein KIF2C between cysteines 262 and 560. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
5mio
Structure name
kif2c-darpin fusion protein bound to tubulin
Structure deposition date
2016-11-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
14
% buried
96
Peptide accession
Q99661
Residue number A
262
Residue number B
560
Peptide name
Kinesin-like protein KIF2C
Ligandability
Cysteine 262 of Kinesin-like protein KIF2C
Cysteine 560 of Kinesin-like protein KIF2C
4ubf A 260 A 344
A redox-regulated disulphide may form within Kinesin-like protein KIF2C between cysteines 260 and 344. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
4ubf
Structure name
hsmcak motor domain complex
Structure deposition date
2014-08-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
90
Minimum pKa ?
9
% buried
98
Peptide accession
Q99661
Residue number A
260
Residue number B
344
Peptide name
Kinesin-like protein KIF2C
Ligandability
Cysteine 260 of Kinesin-like protein KIF2C
Cysteine 344 of Kinesin-like protein KIF2C
1v8j A 76 A 158
A redox-regulated disulphide may form within Kinesin-like protein KIF2C between cysteines 258 and 340 (76 and 158 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
1v8j
Structure name
the crystal structure of the minimal functional domain of the microtubule destabilizer kif2c complexed with mg-adp
Structure deposition date
2004-01-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
92
Minimum pKa ?
9
% buried
100
Peptide accession
Q922S8
Residue number A
258
Residue number B
340
Peptide name
Kinesin-like protein KIF2C
Ligandability
Cysteine 258 of Kinesin-like protein KIF2C
Cysteine 340 of Kinesin-like protein KIF2C
5xjb B 241 B 256
A redox-regulated disulphide may form within Kinesin-like protein KIF2C between cysteines 241 and 256. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
5xjb
Structure name
the crystal structure of the minimal core domain of the microtubule depolymerizer kif2c complexed with adp-mg-befx
Structure deposition date
2017-04-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
9
% buried
68
Peptide accession
Q922S8
Residue number A
241
Residue number B
256
Peptide name
Kinesin-like protein KIF2C
Ligandability
Cysteine 241 of Kinesin-like protein KIF2C
Cysteine 256 of Kinesin-like protein KIF2C
5xjb A 241 A 258
A redox-regulated disulphide may form within Kinesin-like protein KIF2C between cysteines 241 and 258. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
5xjb
Structure name
the crystal structure of the minimal core domain of the microtubule depolymerizer kif2c complexed with adp-mg-befx
Structure deposition date
2017-04-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
72
Peptide accession
Q922S8
Residue number A
241
Residue number B
258
Peptide name
Kinesin-like protein KIF2C
Ligandability
Cysteine 241 of Kinesin-like protein KIF2C
Cysteine 258 of Kinesin-like protein KIF2C
1v8k A 74 A 101
A redox-regulated disulphide may form within Kinesin-like protein KIF2C between cysteines 256 and 283 (74 and 101 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
1v8k
Structure name
the crystal structure of the minimal functional domain of the microtubule destabilizer kif2c complexed with mg-amppnp
Structure deposition date
2004-01-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
72
Peptide accession
Q922S8
Residue number A
256
Residue number B
283
Peptide name
Kinesin-like protein KIF2C
Ligandability
Cysteine 256 of Kinesin-like protein KIF2C
Cysteine 283 of Kinesin-like protein KIF2C
1v8j A 76 A 101
A redox-regulated disulphide may form within Kinesin-like protein KIF2C between cysteines 258 and 283 (76 and 101 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
1v8j
Structure name
the crystal structure of the minimal functional domain of the microtubule destabilizer kif2c complexed with mg-adp
Structure deposition date
2004-01-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
15
% buried
nan
Peptide accession
Q922S8
Residue number A
258
Residue number B
283
Peptide name
Kinesin-like protein KIF2C
Ligandability
Cysteine 258 of Kinesin-like protein KIF2C
Cysteine 283 of Kinesin-like protein KIF2C
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