ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Docking protein 1

Intramolecular
Cysteine 168 and cysteine 224
A redox-regulated disulphide may form within Docking protein 1 between cysteines 168 and 224 (20 and 76 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2v76
Structure name
crystal structure of the human dok1 ptb domain
Structure deposition date
2007-07-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
47
Minimum pKa ?
10
% buried
32
Peptide accession
Q53TY2
Residue number A
168
Residue number B
224
Peptide name
Docking protein 1

Ligandability

Cysteine 168 of Docking protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 224 of Docking protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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