ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Killer cell immunoglobulin-like receptor 2DL4

Intramolecular
Cysteine 33 and cysteine 51
Cysteine 146 and cysteine 195
Cysteine 33 and cysteine 97
Cysteine 51 and cysteine 97
A redox-regulated disulphide may form within Killer cell immunoglobulin-like receptor 2DL4 between cysteines 33 and 51 (10 and 28 respectively in this structure).

Details

Redox score ?
86
PDB code
3wyr
Structure name
crystal structure of killer cell immunoglobulin-like receptor 2dl4
Structure deposition date
2014-09-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99706
Residue number A
33
Residue number B
51
Peptide name
Killer cell immunoglobulin-like receptor 2DL4

Ligandability

Cysteine 33 of Killer cell immunoglobulin-like receptor 2DL4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 51 of Killer cell immunoglobulin-like receptor 2DL4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Killer cell immunoglobulin-like receptor 2DL4 between cysteines 146 and 195 (123 and 172 respectively in this structure).

Details

Redox score ?
81
PDB code
3wyr
Structure name
crystal structure of killer cell immunoglobulin-like receptor 2dl4
Structure deposition date
2014-09-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99706
Residue number A
146
Residue number B
195
Peptide name
Killer cell immunoglobulin-like receptor 2DL4

Ligandability

Cysteine 146 of Killer cell immunoglobulin-like receptor 2DL4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of Killer cell immunoglobulin-like receptor 2DL4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Killer cell immunoglobulin-like receptor 2DL4 between cysteines 33 and 97 (10 and 74 respectively in this structure).

Details

Redox score ?
69
PDB code
3wyr
Structure name
crystal structure of killer cell immunoglobulin-like receptor 2dl4
Structure deposition date
2014-09-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
13
% buried
nan
Peptide accession
Q99706
Residue number A
33
Residue number B
97
Peptide name
Killer cell immunoglobulin-like receptor 2DL4

Ligandability

Cysteine 33 of Killer cell immunoglobulin-like receptor 2DL4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 of Killer cell immunoglobulin-like receptor 2DL4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Killer cell immunoglobulin-like receptor 2DL4 between cysteines 51 and 97 (28 and 74 respectively in this structure).

Details

Redox score ?
62
PDB code
3wyr
Structure name
crystal structure of killer cell immunoglobulin-like receptor 2dl4
Structure deposition date
2014-09-07
Thiol separation (Å)
5
Half-sphere exposure sum ?
80
Minimum pKa ?
13
% buried
nan
Peptide accession
Q99706
Residue number A
51
Residue number B
97
Peptide name
Killer cell immunoglobulin-like receptor 2DL4

Ligandability

Cysteine 51 of Killer cell immunoglobulin-like receptor 2DL4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 of Killer cell immunoglobulin-like receptor 2DL4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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