a tool for identifying drug-targetable redox-active disulphides

Thioredoxin, mitochondrial

Intramolecular

Cysteine 90 and cysteine 93 L

A redox-regulated disulphide may form within Thioredoxin, mitochondrial between cysteines 90 and 93 (31 and 34 respectively in this structure).

Details

Redox score ?

77

PDB code

Structure name

structure of human thioredoxin 2

Structure deposition date

2004-01-27

Thiol separation (Å)

3

Half-sphere exposure sum ?

75

Minimum pK_a ?

8

% buried

83

Peptide accession

Residue number A

90

Residue number B

93

Peptide name

Thioredoxin, mitochondrial

Ligandability

Cysteine 90 of Thioredoxin, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Thioredoxin, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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