ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

5-demethoxyubiquinone hydroxylase, mitochondrial

Intramolecular
Cysteine 137 and cysteine 207
A redox-regulated disulphide may form within 5-demethoxyubiquinone hydroxylase, mitochondrial between cysteines 137 and 207. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7ssp
Structure name
structure of the human coq7:coq9 complex by single-particle electron cryo-microscopy, unliganded state
Structure deposition date
2021-11-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
92
Peptide accession
Q99807
Residue number A
137
Residue number B
207
Peptide name
5-demethoxyubiquinone hydroxylase, mitochondrial

Ligandability

Cysteine 137 of 5-demethoxyubiquinone hydroxylase, mitochondrial

Cysteine 207 of 5-demethoxyubiquinone hydroxylase, mitochondrial

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