ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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T-complex protein 1 subunit eta

Intramolecular
Cysteine 326 and cysteine 345
Cysteine 326 and cysteine 364 L
Cysteine 345 and cysteine 364 L
Cysteine 364 and cysteine 370 L
A redox-regulated disulphide may form within T-complex protein 1 subunit eta between cysteines 326 and 345.

Details

Redox score ?
83
PDB code
4b2t
Structure name
the crystal structures of the eukaryotic chaperonin cct reveal its functional partitioning
Structure deposition date
2012-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2NKZ1
Residue number A
326
Residue number B
345
Peptide name
T-complex protein 1 subunit eta

Ligandability

Cysteine 326 of T-complex protein 1 subunit eta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 345 of T-complex protein 1 subunit eta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-complex protein 1 subunit eta between cysteines 326 and 364.

Details

Redox score ?
81
PDB code
6nrb
Structure name
htric-hpfd class2
Structure deposition date
2019-01-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
5
% buried
90
Peptide accession
Q99832
Residue number A
326
Residue number B
364
Peptide name
T-complex protein 1 subunit eta

Ligandability

Cysteine 326 of T-complex protein 1 subunit eta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 364 of T-complex protein 1 subunit eta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-complex protein 1 subunit eta between cysteines 345 and 364.

Details

Redox score ?
75
PDB code
4b2t
Structure name
the crystal structures of the eukaryotic chaperonin cct reveal its functional partitioning
Structure deposition date
2012-07-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
nan
Peptide accession
Q2NKZ1
Residue number A
345
Residue number B
364
Peptide name
T-complex protein 1 subunit eta

Ligandability

Cysteine 345 of T-complex protein 1 subunit eta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 364 of T-complex protein 1 subunit eta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-complex protein 1 subunit eta between cysteines 364 and 370. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7wu7
Structure name
prefoldin-tubulin-tric complex
Structure deposition date
2022-02-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
62
Peptide accession
Q99832
Residue number A
364
Residue number B
370
Peptide name
T-complex protein 1 subunit eta

Ligandability

Cysteine 364 of T-complex protein 1 subunit eta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 370 of T-complex protein 1 subunit eta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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