ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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HAUS augmin-like complex subunit 7

Intramolecular
Cysteine 144 and cysteine 147
Cysteine 283 and cysteine 284
Cysteine 59 and cysteine 122
A redox-regulated disulphide may form within HAUS augmin-like complex subunit 7 between cysteines 144 and 147 (154 and 157 respectively in this structure).

Details

Redox score ?
61
PDB code
7sqk
Structure name
cryo-em structure of the human augmin complex
Structure deposition date
2021-11-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
0
Peptide accession
Q99871
Residue number A
144
Residue number B
147
Peptide name
HAUS augmin-like complex subunit 7

Ligandability

Cysteine 144 of HAUS augmin-like complex subunit 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 147 of HAUS augmin-like complex subunit 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HAUS augmin-like complex subunit 7 between cysteines 283 and 284 (293 and 294 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
7sqk
Structure name
cryo-em structure of the human augmin complex
Structure deposition date
2021-11-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
33
Peptide accession
Q99871
Residue number A
283
Residue number B
284
Peptide name
HAUS augmin-like complex subunit 7

Ligandability

Cysteine 283 of HAUS augmin-like complex subunit 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 284 of HAUS augmin-like complex subunit 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HAUS augmin-like complex subunit 7 between cysteines 59 and 122 (69 and 132 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7sqk
Structure name
cryo-em structure of the human augmin complex
Structure deposition date
2021-11-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
25
Peptide accession
Q99871
Residue number A
59
Residue number B
122
Peptide name
HAUS augmin-like complex subunit 7

Ligandability

Cysteine 59 of HAUS augmin-like complex subunit 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of HAUS augmin-like complex subunit 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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