ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein arginine N-methyltransferase 1

Intramolecular
Cysteine 232 and cysteine 254
Cysteine 342 and cysteine 346
A redox-regulated disulphide may form within Protein arginine N-methyltransferase 1 between cysteines 232 and 254.

Details

Redox score ?
64
PDB code
1orh
Structure name
structure of the predominant protein arginine methyltransferase prmt1
Structure deposition date
2003-03-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
15
Peptide accession
Q63009
Residue number A
232
Residue number B
254
Peptide name
Protein arginine N-methyltransferase 1

Ligandability

Cysteine 232 of Protein arginine N-methyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 254 of Protein arginine N-methyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein arginine N-methyltransferase 1 between cysteines 342 and 346. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3q7e
Structure name
crystal structure of rat protein arginine methyltransferase 1 (prmt1) m48l mutant
Structure deposition date
2011-01-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
32
Peptide accession
Q63009
Residue number A
342
Residue number B
346
Peptide name
Protein arginine N-methyltransferase 1

Ligandability

Cysteine 342 of Protein arginine N-methyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 346 of Protein arginine N-methyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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