Tyrosine-protein phosphatase non-receptor type 18
Intramolecular
Cysteine 131 and cysteine 141
Cysteine 131 and cysteine 229
Cysteine 229 and cysteine 233
Cysteine 141 and cysteine 229
Cysteine 229 and cysteine 240
Cysteine 226 and cysteine 240
4nnd A 131 A 141
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 18 between cysteines 131 and 141.
Details
Redox score ?
68
PDB code
4nnd
Structure name
structural basis of ptpn18 fingerprint on distinct her2 tyrosine phosphorylation sites
Structure deposition date
2013-11-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
9
% buried
100
Peptide accession
Q99952
Residue number A
131
Residue number B
141
Peptide name
Tyrosine-protein phosphatase non-receptor type 18
Ligandability
Cysteine 131 of Tyrosine-protein phosphatase non-receptor type 18
Cysteine 141 of Tyrosine-protein phosphatase non-receptor type 18
2oc3 A 131 A 229
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 18 between cysteines 131 and 229. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
2oc3
Structure name
crystal structure of the catalytic domain of human protein tyrosine phosphatase non-receptor type 18
Structure deposition date
2006-12-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
82
Minimum pKa ?
8
% buried
98
Peptide accession
Q99952
Residue number A
131
Residue number B
229
Peptide name
Tyrosine-protein phosphatase non-receptor type 18
Ligandability
Cysteine 131 of Tyrosine-protein phosphatase non-receptor type 18
Cysteine 229 of Tyrosine-protein phosphatase non-receptor type 18
2oc3 A 229 A 233
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 18 between cysteines 229 and 233. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
2oc3
Structure name
crystal structure of the catalytic domain of human protein tyrosine phosphatase non-receptor type 18
Structure deposition date
2006-12-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
87
Minimum pKa ?
8
% buried
98
Peptide accession
Q99952
Residue number A
229
Residue number B
233
Peptide name
Tyrosine-protein phosphatase non-receptor type 18
Ligandability
Cysteine 229 of Tyrosine-protein phosphatase non-receptor type 18
Cysteine 233 of Tyrosine-protein phosphatase non-receptor type 18
2oc3 A 141 A 229
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 18 between cysteines 141 and 229. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
2oc3
Structure name
crystal structure of the catalytic domain of human protein tyrosine phosphatase non-receptor type 18
Structure deposition date
2006-12-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
8
% buried
98
Peptide accession
Q99952
Residue number A
141
Residue number B
229
Peptide name
Tyrosine-protein phosphatase non-receptor type 18
Ligandability
Cysteine 141 of Tyrosine-protein phosphatase non-receptor type 18
Cysteine 229 of Tyrosine-protein phosphatase non-receptor type 18
2oc3 A 229 A 240
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 18 between cysteines 229 and 240. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
2oc3
Structure name
crystal structure of the catalytic domain of human protein tyrosine phosphatase non-receptor type 18
Structure deposition date
2006-12-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
94
Minimum pKa ?
8
% buried
100
Peptide accession
Q99952
Residue number A
229
Residue number B
240
Peptide name
Tyrosine-protein phosphatase non-receptor type 18
Ligandability
Cysteine 229 of Tyrosine-protein phosphatase non-receptor type 18
Cysteine 240 of Tyrosine-protein phosphatase non-receptor type 18
4nnd G 226 G 240
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 18 between cysteines 226 and 240. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
26
PDB code
4nnd
Structure name
structural basis of ptpn18 fingerprint on distinct her2 tyrosine phosphorylation sites
Structure deposition date
2013-11-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
96
Minimum pKa ?
12
% buried
100
Peptide accession
Q99952
Residue number A
226
Residue number B
240
Peptide name
Tyrosine-protein phosphatase non-receptor type 18
Ligandability
Cysteine 226 of Tyrosine-protein phosphatase non-receptor type 18
Cysteine 240 of Tyrosine-protein phosphatase non-receptor type 18
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