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a tool for identifying drug-targetable redox-active disulphides

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Growth/differentiation factor 15

Intermolecular
Cysteine 273 and cysteine 273
Cysteine 274 and cysteine 273
Cysteine 244 and cysteine 273
Cysteine 211 and cysteine 273
Cysteine 240 and cysteine 273
Cysteine 307 and cysteine 273
Intramolecular
Cysteine 203 and cysteine 210
Cysteine 240 and cysteine 305
Cysteine 244 and cysteine 307
Cysteine 211 and cysteine 274
More...
Cysteine 211 and cysteine 307
Cysteine 211 and cysteine 244
Cysteine 274 and cysteine 305
Cysteine 240 and cysteine 274
Cysteine 211 and cysteine 305
Cysteine 244 and cysteine 274
Cysteine 211 and cysteine 240
Cysteine 274 and cysteine 307
Cysteine 210 and cysteine 307
Cysteine 210 and cysteine 244
Cysteine 210 and cysteine 211
Cysteine 305 and cysteine 307
Cysteine 244 and cysteine 305
Cysteine 203 and cysteine 307
Cysteine 210 and cysteine 274
Cysteine 203 and cysteine 211
Cysteine 203 and cysteine 244
Cysteine 240 and cysteine 244
Cysteine 240 and cysteine 307
A redox-regulated disulphide may form between two units of Growth/differentiation factor 15 at cysteines 273 and 273 (77 and 77 respectively in this structure).

Details

Redox score ?
74
PDB code
5vt2
Structure name
crystal structure of growth differentiation factor
Structure deposition date
2017-05-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide A name
Growth/differentiation factor 15
Peptide B name
Growth/differentiation factor 15
Peptide A accession
Q99988
Peptide B accession
Q99988
Peptide A residue number
273
Peptide B residue number
273

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Growth/differentiation factor 15 at cysteines 274 and 273 (78 and 77 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
5vt2
Structure name
crystal structure of growth differentiation factor
Structure deposition date
2017-05-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide A name
Growth/differentiation factor 15
Peptide B name
Growth/differentiation factor 15
Peptide A accession
Q99988
Peptide B accession
Q99988
Peptide A residue number
274
Peptide B residue number
273

Ligandability

Cysteine 274 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 273 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Growth/differentiation factor 15 at cysteines 244 and 273 (48 and 77 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5vt2
Structure name
crystal structure of growth differentiation factor
Structure deposition date
2017-05-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide A name
Growth/differentiation factor 15
Peptide B name
Growth/differentiation factor 15
Peptide A accession
Q99988
Peptide B accession
Q99988
Peptide A residue number
244
Peptide B residue number
273

Ligandability

Cysteine 244 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 273 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Growth/differentiation factor 15 at cysteines 211 and 273 (15 and 77 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5vt2
Structure name
crystal structure of growth differentiation factor
Structure deposition date
2017-05-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide A name
Growth/differentiation factor 15
Peptide B name
Growth/differentiation factor 15
Peptide A accession
Q99988
Peptide B accession
Q99988
Peptide A residue number
211
Peptide B residue number
273

Ligandability

Cysteine 211 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 273 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Growth/differentiation factor 15 at cysteines 240 and 273 (44 and 77 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5vt2
Structure name
crystal structure of growth differentiation factor
Structure deposition date
2017-05-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide A name
Growth/differentiation factor 15
Peptide B name
Growth/differentiation factor 15
Peptide A accession
Q99988
Peptide B accession
Q99988
Peptide A residue number
240
Peptide B residue number
273

Ligandability

Cysteine 240 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 273 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Growth/differentiation factor 15 at cysteines 307 and 273 (111 and 77 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5vt2
Structure name
crystal structure of growth differentiation factor
Structure deposition date
2017-05-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide A name
Growth/differentiation factor 15
Peptide B name
Growth/differentiation factor 15
Peptide A accession
Q99988
Peptide B accession
Q99988
Peptide A residue number
307
Peptide B residue number
273

Ligandability

Cysteine 307 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 273 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 203 and 210 (7 and 14 respectively in this structure).

Details

Redox score ?
87
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
203
Residue number B
210
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 203 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 240 and 305 (44 and 109 respectively in this structure).

Details

Redox score ?
86
PDB code
5vz3
Structure name
growth factor crystal structure at 1
Structure deposition date
2017-05-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
240
Residue number B
305
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 240 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 305 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 244 and 307 (48 and 111 respectively in this structure).

Details

Redox score ?
85
PDB code
5vz3
Structure name
growth factor crystal structure at 1
Structure deposition date
2017-05-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
244
Residue number B
307
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 244 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 307 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 211 and 274 (15 and 78 respectively in this structure).

Details

Redox score ?
85
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
211
Residue number B
274
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 211 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 274 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 211 and 307 (15 and 111 respectively in this structure).

Details

Redox score ?
73
PDB code
5vz3
Structure name
growth factor crystal structure at 1
Structure deposition date
2017-05-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
211
Residue number B
307
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 211 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 307 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 211 and 244 (15 and 48 respectively in this structure).

Details

Redox score ?
71
PDB code
5vt2
Structure name
crystal structure of growth differentiation factor
Structure deposition date
2017-05-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
211
Residue number B
244
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 211 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 244 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 274 and 305 (78 and 109 respectively in this structure).

Details

Redox score ?
70
PDB code
5vz3
Structure name
growth factor crystal structure at 1
Structure deposition date
2017-05-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
274
Residue number B
305
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 274 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 305 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 240 and 274 (44 and 78 respectively in this structure).

Details

Redox score ?
69
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
240
Residue number B
274
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 240 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 274 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 211 and 305 (15 and 109 respectively in this structure).

Details

Redox score ?
68
PDB code
5vt2
Structure name
crystal structure of growth differentiation factor
Structure deposition date
2017-05-15
Thiol separation (Å)
5
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
211
Residue number B
305
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 211 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 305 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 244 and 274 (48 and 78 respectively in this structure).

Details

Redox score ?
66
PDB code
5vt2
Structure name
crystal structure of growth differentiation factor
Structure deposition date
2017-05-15
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
244
Residue number B
274
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 244 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 274 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 211 and 240 (15 and 44 respectively in this structure).

Details

Redox score ?
63
PDB code
5vt2
Structure name
crystal structure of growth differentiation factor
Structure deposition date
2017-05-15
Thiol separation (Å)
5
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
211
Residue number B
240
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 211 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 240 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 274 and 307 (78 and 111 respectively in this structure).

Details

Redox score ?
60
PDB code
5vt2
Structure name
crystal structure of growth differentiation factor
Structure deposition date
2017-05-15
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
274
Residue number B
307
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 274 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 307 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 210 and 307 (14 and 111 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
210
Residue number B
307
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 210 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 307 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 210 and 244 (14 and 48 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
5vt2
Structure name
crystal structure of growth differentiation factor
Structure deposition date
2017-05-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
210
Residue number B
244
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 210 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 244 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 210 and 211 (14 and 15 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5vz3
Structure name
growth factor crystal structure at 1
Structure deposition date
2017-05-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
210
Residue number B
211
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 210 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 211 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 305 and 307 (109 and 111 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
5vt2
Structure name
crystal structure of growth differentiation factor
Structure deposition date
2017-05-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
305
Residue number B
307
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 305 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 307 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 244 and 305 (48 and 109 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
244
Residue number B
305
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 244 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 305 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 203 and 307 (7 and 111 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
203
Residue number B
307
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 203 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 307 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 210 and 274 (14 and 78 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5vz3
Structure name
growth factor crystal structure at 1
Structure deposition date
2017-05-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
210
Residue number B
274
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 210 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 274 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 203 and 211 (7 and 15 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
5vz4
Structure name
receptor-growth factor crystal structure at 2
Structure deposition date
2017-05-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
203
Residue number B
211
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 203 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 211 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 203 and 244 (7 and 48 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
5vt2
Structure name
crystal structure of growth differentiation factor
Structure deposition date
2017-05-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
203
Residue number B
244
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 203 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 244 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 240 and 244 (44 and 48 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
5vt2
Structure name
crystal structure of growth differentiation factor
Structure deposition date
2017-05-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
240
Residue number B
244
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 240 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 244 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth/differentiation factor 15 between cysteines 240 and 307 (44 and 111 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
5vt2
Structure name
crystal structure of growth differentiation factor
Structure deposition date
2017-05-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99988
Residue number A
240
Residue number B
307
Peptide name
Growth/differentiation factor 15

Ligandability

Cysteine 240 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 307 of Growth/differentiation factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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