ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Growth arrest and DNA-damage-inducible 45 gamma

Intramolecular
Cysteine 60 and cysteine 119
Cysteine 60 and cysteine 85
Cysteine 85 and cysteine 86
Cysteine 85 and cysteine 119
Cysteine 86 and cysteine 142
Cysteine 60 and cysteine 86
A redox-regulated disulphide may form within Growth arrest and DNA-damage-inducible 45 gamma between cysteines 60 and 119.

Details

Redox score ?
69
PDB code
3cg6
Structure name
crystal structure of gadd45 gamma
Structure deposition date
2008-03-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
91
Minimum pKa ?
8
% buried
94
Peptide accession
Q99M58
Residue number A
60
Residue number B
119
Peptide name
Growth arrest and DNA-damage-inducible 45 gamma

Ligandability

Cysteine 60 of Growth arrest and DNA-damage-inducible 45 gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 119 of Growth arrest and DNA-damage-inducible 45 gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth arrest and DNA-damage-inducible 45 gamma between cysteines 60 and 85.

Details

Redox score ?
69
PDB code
3cg6
Structure name
crystal structure of gadd45 gamma
Structure deposition date
2008-03-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
9
% buried
87
Peptide accession
Q99M58
Residue number A
60
Residue number B
85
Peptide name
Growth arrest and DNA-damage-inducible 45 gamma

Ligandability

Cysteine 60 of Growth arrest and DNA-damage-inducible 45 gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 85 of Growth arrest and DNA-damage-inducible 45 gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth arrest and DNA-damage-inducible 45 gamma between cysteines 85 and 86. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
3cg6
Structure name
crystal structure of gadd45 gamma
Structure deposition date
2008-03-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
8
% buried
50
Peptide accession
Q99M58
Residue number A
85
Residue number B
86
Peptide name
Growth arrest and DNA-damage-inducible 45 gamma

Ligandability

Cysteine 85 of Growth arrest and DNA-damage-inducible 45 gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 86 of Growth arrest and DNA-damage-inducible 45 gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth arrest and DNA-damage-inducible 45 gamma between cysteines 85 and 119. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
3cg6
Structure name
crystal structure of gadd45 gamma
Structure deposition date
2008-03-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
8
% buried
82
Peptide accession
Q99M58
Residue number A
85
Residue number B
119
Peptide name
Growth arrest and DNA-damage-inducible 45 gamma

Ligandability

Cysteine 85 of Growth arrest and DNA-damage-inducible 45 gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 119 of Growth arrest and DNA-damage-inducible 45 gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth arrest and DNA-damage-inducible 45 gamma between cysteines 86 and 142. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3cg6
Structure name
crystal structure of gadd45 gamma
Structure deposition date
2008-03-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
48
Peptide accession
Q99M58
Residue number A
86
Residue number B
142
Peptide name
Growth arrest and DNA-damage-inducible 45 gamma

Ligandability

Cysteine 86 of Growth arrest and DNA-damage-inducible 45 gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 142 of Growth arrest and DNA-damage-inducible 45 gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth arrest and DNA-damage-inducible 45 gamma between cysteines 60 and 86. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
3cg6
Structure name
crystal structure of gadd45 gamma
Structure deposition date
2008-03-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
63
Peptide accession
Q99M58
Residue number A
60
Residue number B
86
Peptide name
Growth arrest and DNA-damage-inducible 45 gamma

Ligandability

Cysteine 60 of Growth arrest and DNA-damage-inducible 45 gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 86 of Growth arrest and DNA-damage-inducible 45 gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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