ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dihydropyrimidinase-related protein 5

Intramolecular
Cysteine 125 and cysteine 454
Cysteine 181 and cysteine 241
Cysteine 126 and cysteine 454
Cysteine 125 and cysteine 126
Cysteine 126 and cysteine 462
A redox-regulated disulphide may form within Dihydropyrimidinase-related protein 5 between cysteines 125 and 454.

Details

Redox score ?
76
PDB code
4b92
Structure name
crystal structure of truncated human crmp-5 soaked with zn
Structure deposition date
2012-08-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
7
% buried
62
Peptide accession
Q9BPU6
Residue number A
125
Residue number B
454
Peptide name
Dihydropyrimidinase-related protein 5

Ligandability

Cysteine 125 of Dihydropyrimidinase-related protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 454 of Dihydropyrimidinase-related protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dihydropyrimidinase-related protein 5 between cysteines 181 and 241. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
4b91
Structure name
crystal structure of truncated human crmp-5
Structure deposition date
2012-08-31
Thiol separation (Å)
5
Half-sphere exposure sum ?
81
Minimum pKa ?
13
% buried
100
Peptide accession
Q9BPU6
Residue number A
181
Residue number B
241
Peptide name
Dihydropyrimidinase-related protein 5

Ligandability

Cysteine 181 of Dihydropyrimidinase-related protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 241 of Dihydropyrimidinase-related protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dihydropyrimidinase-related protein 5 between cysteines 126 and 454. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
4b91
Structure name
crystal structure of truncated human crmp-5
Structure deposition date
2012-08-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
7
% buried
78
Peptide accession
Q9BPU6
Residue number A
126
Residue number B
454
Peptide name
Dihydropyrimidinase-related protein 5

Ligandability

Cysteine 126 of Dihydropyrimidinase-related protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 454 of Dihydropyrimidinase-related protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dihydropyrimidinase-related protein 5 between cysteines 125 and 126. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
4b91
Structure name
crystal structure of truncated human crmp-5
Structure deposition date
2012-08-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
93
Minimum pKa ?
14
% buried
82
Peptide accession
Q9BPU6
Residue number A
125
Residue number B
126
Peptide name
Dihydropyrimidinase-related protein 5

Ligandability

Cysteine 125 of Dihydropyrimidinase-related protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Dihydropyrimidinase-related protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dihydropyrimidinase-related protein 5 between cysteines 126 and 462. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
4b91
Structure name
crystal structure of truncated human crmp-5
Structure deposition date
2012-08-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
92
Peptide accession
Q9BPU6
Residue number A
126
Residue number B
462
Peptide name
Dihydropyrimidinase-related protein 5

Ligandability

Cysteine 126 of Dihydropyrimidinase-related protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 462 of Dihydropyrimidinase-related protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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