ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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17-beta-hydroxysteroid dehydrogenase 14

Intermolecular
Cysteine 255 and cysteine 255
Intramolecular
Cysteine 39 and cysteine 61
A redox-regulated disulphide may form between two units of 17-beta-hydroxysteroid dehydrogenase 14 at cysteines 255 and 255.

Details

Redox score ?
79
PDB code
5ics
Structure name
crystal structure of 17beta-hydroxysteroid dehydrogenase type 14 apoenzyme
Structure deposition date
2016-02-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide A name
17-beta-hydroxysteroid dehydrogenase 14
Peptide B name
17-beta-hydroxysteroid dehydrogenase 14
Peptide A accession
Q9BPX1
Peptide B accession
Q9BPX1
Peptide A residue number
255
Peptide B residue number
255

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 17-beta-hydroxysteroid dehydrogenase 14 between cysteines 39 and 61.

Details

Redox score ?
71
PDB code
6qck
Structure name
17beta-hydroxysteroid dehydrogenase 14 variant t205 in complex with fb262
Structure deposition date
2018-12-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
8
% buried
83
Peptide accession
Q9BPX1
Residue number A
39
Residue number B
61
Peptide name
17-beta-hydroxysteroid dehydrogenase 14

Ligandability

Cysteine 39 of 17-beta-hydroxysteroid dehydrogenase 14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 61 of 17-beta-hydroxysteroid dehydrogenase 14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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