ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Calcium uptake protein 1, mitochondrial

Intermolecular
Cysteine 413 of Calcium uptake protein 2, mitochondrial and cysteine 463
Intramolecular
Cysteine 201 and cysteine 275 L
A redox-regulated disulphide is known to form between cysteine 413 of Calcium uptake protein 2, mitochondrial and cysteine 463 of Calcium uptake protein 1, mitochondrial.

Details

Redox score ?
85
PDB code
6wdn
Structure name
cryo-em structure of mitochondrial calcium uniporter holocomplex in low ca2+
Structure deposition date
2020-04-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide A name
Calcium uptake protein 2, mitochondrial
Peptide B name
Calcium uptake protein 1, mitochondrial
Peptide A accession
Q8IYU8
Peptide B accession
Q9BPX6
Peptide A residue number
413
Peptide B residue number
463

Ligandability

Cysteine 413 of Calcium uptake protein 2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 463 of Calcium uptake protein 1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Calcium uptake protein 1, mitochondrial between cysteines 201 and 275. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
6lb7
Structure name
crystal structure of the ca2+-free and ca2+-bound micu1-micu2 complex
Structure deposition date
2019-11-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
32
Peptide accession
Q9BPX6
Residue number A
201
Residue number B
275
Peptide name
Calcium uptake protein 1, mitochondrial

Ligandability

Cysteine 201 of Calcium uptake protein 1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 275 of Calcium uptake protein 1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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