ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Target of rapamycin complex 2 subunit MAPKAP1

Intermolecular
Cysteine 187 of Rapamycin-insensitive companion of mTOR and cysteine 27
Cysteine 192 of Rapamycin-insensitive companion of mTOR and cysteine 27
A redox-regulated disulphide may form between cysteine 187 of Rapamycin-insensitive companion of mTOR and cysteine 27 of Target of rapamycin complex 2 subunit MAPKAP1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6zwm
Structure name
cryo-em structure of human mtor complex 2, overall refinement
Structure deposition date
2020-07-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
88
Peptide A name
Rapamycin-insensitive companion of mTOR
Peptide B name
Target of rapamycin complex 2 subunit MAPKAP1
Peptide A accession
Q6R327
Peptide B accession
Q9BPZ7
Peptide A residue number
187
Peptide B residue number
27

Ligandability

Cysteine 187 of Rapamycin-insensitive companion of mTOR

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 27 of Target of rapamycin complex 2 subunit MAPKAP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 192 of Rapamycin-insensitive companion of mTOR and cysteine 27 of Target of rapamycin complex 2 subunit MAPKAP1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
6zwm
Structure name
cryo-em structure of human mtor complex 2, overall refinement
Structure deposition date
2020-07-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
13
% buried
86
Peptide A name
Rapamycin-insensitive companion of mTOR
Peptide B name
Target of rapamycin complex 2 subunit MAPKAP1
Peptide A accession
Q6R327
Peptide B accession
Q9BPZ7
Peptide A residue number
192
Peptide B residue number
27

Ligandability

Cysteine 192 of Rapamycin-insensitive companion of mTOR

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 27 of Target of rapamycin complex 2 subunit MAPKAP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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