ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Three prime repair exonuclease 2

Intramolecular
Cysteine 63 and cysteine 88
Cysteine 113 and cysteine 144
Cysteine 128 and cysteine 144
A redox-regulated disulphide may form within Three prime repair exonuclease 2 between cysteines 63 and 88. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6a4b
Structure name
structure of trex2 in complex with a duplex dna with 2 nucleotide 3'- overhang
Structure deposition date
2018-06-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
10
% buried
80
Peptide accession
Q9R1A9
Residue number A
63
Residue number B
88
Peptide name
Three prime repair exonuclease 2

Ligandability

Cysteine 63 of Three prime repair exonuclease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of Three prime repair exonuclease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Three prime repair exonuclease 2 between cysteines 113 and 144. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6a47
Structure name
structure of trex2 in complex with a y structured dsdna
Structure deposition date
2018-06-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
90
Minimum pKa ?
13
% buried
96
Peptide accession
Q9R1A9
Residue number A
113
Residue number B
144
Peptide name
Three prime repair exonuclease 2

Ligandability

Cysteine 113 of Three prime repair exonuclease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 144 of Three prime repair exonuclease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Three prime repair exonuclease 2 between cysteines 128 and 144. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
6a4b
Structure name
structure of trex2 in complex with a duplex dna with 2 nucleotide 3'- overhang
Structure deposition date
2018-06-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
70
Peptide accession
Q9R1A9
Residue number A
128
Residue number B
144
Peptide name
Three prime repair exonuclease 2

Ligandability

Cysteine 128 of Three prime repair exonuclease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 144 of Three prime repair exonuclease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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