ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sentrin-specific protease 7

Intramolecular
Cysteine 867 and cysteine 934
Cysteine 930 and cysteine 934
A redox-regulated disulphide may form within Sentrin-specific protease 7 between cysteines 867 and 934 (801 and 868 respectively in this structure).

Details

Redox score ?
61
PDB code
7r2e
Structure name
structure of human senp7 with sumo2
Structure deposition date
2022-02-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
82
Minimum pKa ?
9
% buried
96
Peptide accession
Q9BQF6
Residue number A
867
Residue number B
934
Peptide name
Sentrin-specific protease 7

Ligandability

Cysteine 867 of Sentrin-specific protease 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 934 of Sentrin-specific protease 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sentrin-specific protease 7 between cysteines 930 and 934 (864 and 868 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7r2e
Structure name
structure of human senp7 with sumo2
Structure deposition date
2022-02-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
56
Peptide accession
Q9BQF6
Residue number A
930
Residue number B
934
Peptide name
Sentrin-specific protease 7

Ligandability

Cysteine 930 of Sentrin-specific protease 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 934 of Sentrin-specific protease 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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