a tool for identifying drug-targetable redox-active disulphides

Golgi reassembly-stacking protein 1

Intermolecular

Cysteine 173 and cysteine 984 of Golgin subfamily A member 2 L

A redox-regulated disulphide may form between cysteine 173 of Golgi reassembly-stacking protein 1 and cysteine 984 of Golgin subfamily A member 2 (173 and 972 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

47

PDB code

Structure name

crystal structure of the grasp65-gm130 c-terminal peptide complex

Structure deposition date

2014-09-24

Thiol separation (Å)

8

Half-sphere exposure sum ?

56

Minimum pK_a ?

11

% buried

72

Peptide A name

Golgi reassembly-stacking protein 1

Peptide B name

Golgin subfamily A member 2

Peptide A accession

Peptide B accession

Peptide A residue number

173

Peptide B residue number

984

Ligandability

Cysteine 173 of Golgi reassembly-stacking protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 984 of Golgin subfamily A member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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