ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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FYVE and coiled-coil domain-containing protein 1

Intramolecular
Cysteine 77 and cysteine 124
Cysteine 75 and cysteine 77
Cysteine 75 and cysteine 124
A redox-regulated disulphide may form within FYVE and coiled-coil domain-containing protein 1 between cysteines 77 and 124.

Details

Redox score ?
73
PDB code
7bqi
Structure name
crystal structure of fyco1 run domain
Structure deposition date
2020-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
8
% buried
82
Peptide accession
Q9BQS8
Residue number A
77
Residue number B
124
Peptide name
FYVE and coiled-coil domain-containing protein 1

Ligandability

Cysteine 77 of FYVE and coiled-coil domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 124 of FYVE and coiled-coil domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within FYVE and coiled-coil domain-containing protein 1 between cysteines 75 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7bqi
Structure name
crystal structure of fyco1 run domain
Structure deposition date
2020-03-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
8
% buried
62
Peptide accession
Q9BQS8
Residue number A
75
Residue number B
77
Peptide name
FYVE and coiled-coil domain-containing protein 1

Ligandability

Cysteine 75 of FYVE and coiled-coil domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of FYVE and coiled-coil domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within FYVE and coiled-coil domain-containing protein 1 between cysteines 75 and 124. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7bqi
Structure name
crystal structure of fyco1 run domain
Structure deposition date
2020-03-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
80
Peptide accession
Q9BQS8
Residue number A
75
Residue number B
124
Peptide name
FYVE and coiled-coil domain-containing protein 1

Ligandability

Cysteine 75 of FYVE and coiled-coil domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 124 of FYVE and coiled-coil domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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