ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Matrix remodeling-associated protein 8

Intramolecular
Cysteine 144 and cysteine 279
Cysteine 137 and cysteine 186
Cysteine 54 and cysteine 272
A redox-regulated disulphide may form within Matrix remodeling-associated protein 8 between cysteines 144 and 279.

Details

Redox score ?
85
PDB code
6jo8
Structure name
the complex structure of chikv envelope glycoprotein bound to human mxra8
Structure deposition date
2019-03-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BRK3
Residue number A
144
Residue number B
279
Peptide name
Matrix remodeling-associated protein 8

Ligandability

Cysteine 144 of Matrix remodeling-associated protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of Matrix remodeling-associated protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Matrix remodeling-associated protein 8 between cysteines 137 and 186.

Details

Redox score ?
82
PDB code
6jo8
Structure name
the complex structure of chikv envelope glycoprotein bound to human mxra8
Structure deposition date
2019-03-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BRK3
Residue number A
137
Residue number B
186
Peptide name
Matrix remodeling-associated protein 8

Ligandability

Cysteine 137 of Matrix remodeling-associated protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Matrix remodeling-associated protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Matrix remodeling-associated protein 8 between cysteines 54 and 272.

Details

Redox score ?
79
PDB code
6jo8
Structure name
the complex structure of chikv envelope glycoprotein bound to human mxra8
Structure deposition date
2019-03-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BRK3
Residue number A
54
Residue number B
272
Peptide name
Matrix remodeling-associated protein 8

Ligandability

Cysteine 54 of Matrix remodeling-associated protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 272 of Matrix remodeling-associated protein 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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