Protein tweety homolog 2
Intermolecular
Cysteine 101 and cysteine 101
Intramolecular
Cysteine 300 and cysteine 367
Cysteine 274 and cysteine 382
Cysteine 69 and cysteine 73
Cysteine 100 and cysteine 227
Cysteine 69 and cysteine 88
Cysteine 247 and cysteine 248
Cysteine 72 and cysteine 88
Cysteine 71 and cysteine 88
Cysteine 227 and cysteine 231
More...Cysteine 71 and cysteine 73
Cysteine 101 and cysteine 231
Cysteine 100 and cysteine 101
Cysteine 100 and cysteine 231
Cysteine 69 and cysteine 71
Cysteine 71 and cysteine 72
Cysteine 69 and cysteine 72
Cysteine 101 and cysteine 227
Cysteine 71 and cysteine 408
Cysteine 69 and cysteine 408
7p54 A 101 B 101
A redox-regulated disulphide may form between two units of Protein tweety homolog 2 at cysteines 101 and 101. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7p54
Structure name
cryo-em structure of human ttyh2 in gdn
Structure deposition date
2021-07-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
58
Minimum pKa ?
7
% buried
48
Peptide A name
Protein tweety homolog 2
Peptide B name
Protein tweety homolog 2
Peptide A accession
Q9BSA4
Peptide B accession
Q9BSA4
Peptide A residue number
101
Peptide B residue number
101
Ligandability
7p54 A 300 A 367
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 300 and 367.
Details
Redox score ?
83
PDB code
7p54
Structure name
cryo-em structure of human ttyh2 in gdn
Structure deposition date
2021-07-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BSA4
Residue number A
300
Residue number B
367
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 300 of Protein tweety homolog 2
Cysteine 367 of Protein tweety homolog 2
7p54 B 274 B 382
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 274 and 382.
Details
Redox score ?
79
PDB code
7p54
Structure name
cryo-em structure of human ttyh2 in gdn
Structure deposition date
2021-07-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BSA4
Residue number A
274
Residue number B
382
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 274 of Protein tweety homolog 2
Cysteine 382 of Protein tweety homolog 2
7p54 B 69 B 73
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 69 and 73.
Details
Redox score ?
71
PDB code
7p54
Structure name
cryo-em structure of human ttyh2 in gdn
Structure deposition date
2021-07-14
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
Q9BSA4
Residue number A
69
Residue number B
73
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 69 of Protein tweety homolog 2
Cysteine 73 of Protein tweety homolog 2
7p5m B 100 B 227
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 100 and 227.
Details
Redox score ?
69
PDB code
7p5m
Structure name
cryo-em structure of human ttyh2 in lipid nanodiscs
Structure deposition date
2021-07-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
9
% buried
68
Peptide accession
Q9BSA4
Residue number A
100
Residue number B
227
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 100 of Protein tweety homolog 2
Cysteine 227 of Protein tweety homolog 2
7rtt B 69 B 73
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 69 and 88 (69 and 73 respectively in this structure).
Details
Redox score ?
67
PDB code
7rtt
Structure name
cryo-em structure of a ttyh2 cis-dimer
Structure deposition date
2021-08-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
Q3TH73
Residue number A
69
Residue number B
88
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 69 of Protein tweety homolog 2
Cysteine 88 of Protein tweety homolog 2
7p54 A 247 A 248
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 247 and 248.
Details
Redox score ?
65
PDB code
7p54
Structure name
cryo-em structure of human ttyh2 in gdn
Structure deposition date
2021-07-14
Thiol separation (Å)
6
Half-sphere exposure sum ?
47
Minimum pKa ?
9
% buried
0
Peptide accession
Q9BSA4
Residue number A
247
Residue number B
248
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 247 of Protein tweety homolog 2
Cysteine 248 of Protein tweety homolog 2
7rtt A 72 A 73
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 72 and 88 (72 and 73 respectively in this structure).
Details
Redox score ?
64
PDB code
7rtt
Structure name
cryo-em structure of a ttyh2 cis-dimer
Structure deposition date
2021-08-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
Q3TH73
Residue number A
72
Residue number B
88
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 72 of Protein tweety homolog 2
Cysteine 88 of Protein tweety homolog 2
7rtt A 71 A 73
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 71 and 88 (71 and 73 respectively in this structure).
Details
Redox score ?
64
PDB code
7rtt
Structure name
cryo-em structure of a ttyh2 cis-dimer
Structure deposition date
2021-08-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
Q3TH73
Residue number A
71
Residue number B
88
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 71 of Protein tweety homolog 2
Cysteine 88 of Protein tweety homolog 2
7p5m B 227 B 231
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 227 and 231.
Details
Redox score ?
63
PDB code
7p5m
Structure name
cryo-em structure of human ttyh2 in lipid nanodiscs
Structure deposition date
2021-07-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
60
Peptide accession
Q9BSA4
Residue number A
227
Residue number B
231
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 227 of Protein tweety homolog 2
Cysteine 231 of Protein tweety homolog 2
7p54 B 71 B 73
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 71 and 73. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
7p54
Structure name
cryo-em structure of human ttyh2 in gdn
Structure deposition date
2021-07-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
Q9BSA4
Residue number A
71
Residue number B
73
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 71 of Protein tweety homolog 2
Cysteine 73 of Protein tweety homolog 2
7p54 A 101 A 231
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 101 and 231. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
7p54
Structure name
cryo-em structure of human ttyh2 in gdn
Structure deposition date
2021-07-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
6
% buried
48
Peptide accession
Q9BSA4
Residue number A
101
Residue number B
231
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 101 of Protein tweety homolog 2
Cysteine 231 of Protein tweety homolog 2
7p5m B 100 B 101
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 100 and 101. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
7p5m
Structure name
cryo-em structure of human ttyh2 in lipid nanodiscs
Structure deposition date
2021-07-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
9
% buried
64
Peptide accession
Q9BSA4
Residue number A
100
Residue number B
101
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 100 of Protein tweety homolog 2
Cysteine 101 of Protein tweety homolog 2
7p54 B 100 B 231
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 100 and 231. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7p54
Structure name
cryo-em structure of human ttyh2 in gdn
Structure deposition date
2021-07-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
6
% buried
59
Peptide accession
Q9BSA4
Residue number A
100
Residue number B
231
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 100 of Protein tweety homolog 2
Cysteine 231 of Protein tweety homolog 2
7p54 A 69 A 71
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 69 and 71. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7p54
Structure name
cryo-em structure of human ttyh2 in gdn
Structure deposition date
2021-07-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
33
Minimum pKa ?
9
% buried
0
Peptide accession
Q9BSA4
Residue number A
69
Residue number B
71
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 69 of Protein tweety homolog 2
Cysteine 71 of Protein tweety homolog 2
7rtv A 71 A 72
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 71 and 72. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7rtv
Structure name
cryo-em structure of monomeric ttyh2
Structure deposition date
2021-08-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
21
Minimum pKa ?
9
% buried
0
Peptide accession
Q3TH73
Residue number A
71
Residue number B
72
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 71 of Protein tweety homolog 2
Cysteine 72 of Protein tweety homolog 2
7rtt A 69 A 72
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 69 and 72. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7rtt
Structure name
cryo-em structure of a ttyh2 cis-dimer
Structure deposition date
2021-08-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
20
Minimum pKa ?
9
% buried
0
Peptide accession
Q3TH73
Residue number A
69
Residue number B
72
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 69 of Protein tweety homolog 2
Cysteine 72 of Protein tweety homolog 2
7p5m B 101 B 227
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 101 and 227. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7p5m
Structure name
cryo-em structure of human ttyh2 in lipid nanodiscs
Structure deposition date
2021-07-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
61
Peptide accession
Q9BSA4
Residue number A
101
Residue number B
227
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 101 of Protein tweety homolog 2
Cysteine 227 of Protein tweety homolog 2
7rtu A 71 A 408
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 71 and 408. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7rtu
Structure name
cryo-em structure of a ttyh2 trans-dimer
Structure deposition date
2021-08-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
46
Minimum pKa ?
10
% buried
8
Peptide accession
Q3TH73
Residue number A
71
Residue number B
408
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 71 of Protein tweety homolog 2
Cysteine 408 of Protein tweety homolog 2
7p5m A 69 A 408
A redox-regulated disulphide may form within Protein tweety homolog 2 between cysteines 69 and 408. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7p5m
Structure name
cryo-em structure of human ttyh2 in lipid nanodiscs
Structure deposition date
2021-07-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
15
Peptide accession
Q9BSA4
Residue number A
69
Residue number B
408
Peptide name
Protein tweety homolog 2
Ligandability
Cysteine 69 of Protein tweety homolog 2
Cysteine 408 of Protein tweety homolog 2
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