Endosomal/lysosomal proton channel TMEM175
Intramolecular
Cysteine 144 and cysteine 196
Cysteine 380 and cysteine 438
Cysteine 144 and cysteine 146
Cysteine 146 and cysteine 196
Cysteine 116 and cysteine 146
6w8n B 144 B 196
A redox-regulated disulphide may form within Endosomal/lysosomal proton channel TMEM175 between cysteines 144 and 196.
Details
Redox score ?
83
PDB code
6w8n
Structure name
structure of a trans-membrane protein
Structure deposition date
2020-03-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BSA9
Residue number A
144
Residue number B
196
Peptide name
Endosomal/lysosomal proton channel TMEM175
Ligandability
Cysteine 144 of Endosomal/lysosomal proton channel TMEM175
Cysteine 196 of Endosomal/lysosomal proton channel TMEM175
6wc9 B 380 B 438
A redox-regulated disulphide may form within Endosomal/lysosomal proton channel TMEM175 between cysteines 380 and 438. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
6wc9
Structure name
human open state tmem175 in kcl
Structure deposition date
2020-03-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
36
Peptide accession
Q9BSA9
Residue number A
380
Residue number B
438
Peptide name
Endosomal/lysosomal proton channel TMEM175
Ligandability
Cysteine 380 of Endosomal/lysosomal proton channel TMEM175
Cysteine 438 of Endosomal/lysosomal proton channel TMEM175
6wcb B 144 B 146
A redox-regulated disulphide may form within Endosomal/lysosomal proton channel TMEM175 between cysteines 144 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
6wcb
Structure name
human open state tmem175 in cscl
Structure deposition date
2020-03-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BSA9
Residue number A
144
Residue number B
146
Peptide name
Endosomal/lysosomal proton channel TMEM175
Ligandability
Cysteine 144 of Endosomal/lysosomal proton channel TMEM175
Cysteine 146 of Endosomal/lysosomal proton channel TMEM175
6w8n B 146 B 196
A redox-regulated disulphide may form within Endosomal/lysosomal proton channel TMEM175 between cysteines 146 and 196. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
6w8n
Structure name
structure of a trans-membrane protein
Structure deposition date
2020-03-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
nan
Peptide accession
Q9BSA9
Residue number A
146
Residue number B
196
Peptide name
Endosomal/lysosomal proton channel TMEM175
Ligandability
Cysteine 146 of Endosomal/lysosomal proton channel TMEM175
Cysteine 196 of Endosomal/lysosomal proton channel TMEM175
7unm A 116 A 146
A redox-regulated disulphide may form within Endosomal/lysosomal proton channel TMEM175 between cysteines 116 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7unm
Structure name
human tmem175 in an closed state
Structure deposition date
2022-04-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
12
% buried
79
Peptide accession
Q9BSA9
Residue number A
116
Residue number B
146
Peptide name
Endosomal/lysosomal proton channel TMEM175
Ligandability
Cysteine 116 of Endosomal/lysosomal proton channel TMEM175
Cysteine 146 of Endosomal/lysosomal proton channel TMEM175
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