ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Endosomal/lysosomal proton channel TMEM175

Intramolecular
Cysteine 144 and cysteine 196
Cysteine 380 and cysteine 438
Cysteine 144 and cysteine 146
Cysteine 146 and cysteine 196
Cysteine 116 and cysteine 146
A redox-regulated disulphide may form within Endosomal/lysosomal proton channel TMEM175 between cysteines 144 and 196.

Details

Redox score ?
83
PDB code
6w8n
Structure name
structure of a trans-membrane protein
Structure deposition date
2020-03-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BSA9
Residue number A
144
Residue number B
196
Peptide name
Endosomal/lysosomal proton channel TMEM175

Ligandability

Cysteine 144 of Endosomal/lysosomal proton channel TMEM175

Cysteine 196 of Endosomal/lysosomal proton channel TMEM175

A redox-regulated disulphide may form within Endosomal/lysosomal proton channel TMEM175 between cysteines 380 and 438. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6wc9
Structure name
human open state tmem175 in kcl
Structure deposition date
2020-03-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
36
Peptide accession
Q9BSA9
Residue number A
380
Residue number B
438
Peptide name
Endosomal/lysosomal proton channel TMEM175

Ligandability

Cysteine 380 of Endosomal/lysosomal proton channel TMEM175

Cysteine 438 of Endosomal/lysosomal proton channel TMEM175

A redox-regulated disulphide may form within Endosomal/lysosomal proton channel TMEM175 between cysteines 144 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6wcb
Structure name
human open state tmem175 in cscl
Structure deposition date
2020-03-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BSA9
Residue number A
144
Residue number B
146
Peptide name
Endosomal/lysosomal proton channel TMEM175

Ligandability

Cysteine 144 of Endosomal/lysosomal proton channel TMEM175

Cysteine 146 of Endosomal/lysosomal proton channel TMEM175

A redox-regulated disulphide may form within Endosomal/lysosomal proton channel TMEM175 between cysteines 146 and 196. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6w8n
Structure name
structure of a trans-membrane protein
Structure deposition date
2020-03-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
nan
Peptide accession
Q9BSA9
Residue number A
146
Residue number B
196
Peptide name
Endosomal/lysosomal proton channel TMEM175

Ligandability

Cysteine 146 of Endosomal/lysosomal proton channel TMEM175

Cysteine 196 of Endosomal/lysosomal proton channel TMEM175

A redox-regulated disulphide may form within Endosomal/lysosomal proton channel TMEM175 between cysteines 116 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7unm
Structure name
human tmem175 in an closed state
Structure deposition date
2022-04-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
12
% buried
79
Peptide accession
Q9BSA9
Residue number A
116
Residue number B
146
Peptide name
Endosomal/lysosomal proton channel TMEM175

Ligandability

Cysteine 116 of Endosomal/lysosomal proton channel TMEM175

Cysteine 146 of Endosomal/lysosomal proton channel TMEM175

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