ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cerebral cavernous malformations 2 protein

Intramolecular
Cysteine 193 and cysteine 194
Cysteine 210 and cysteine 211 L
A redox-regulated disulphide may form within Cerebral cavernous malformations 2 protein between cysteines 193 and 194. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
4wj7
Structure name
ccm2 ptb domain in complex with krit1 npxy/f3
Structure deposition date
2014-09-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
29
Peptide accession
Q9BSQ5
Residue number A
193
Residue number B
194
Peptide name
Cerebral cavernous malformations 2 protein

Ligandability

Cysteine 193 of Cerebral cavernous malformations 2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 194 of Cerebral cavernous malformations 2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cerebral cavernous malformations 2 protein between cysteines 210 and 211. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
4wj7
Structure name
ccm2 ptb domain in complex with krit1 npxy/f3
Structure deposition date
2014-09-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
38
Peptide accession
Q9BSQ5
Residue number A
210
Residue number B
211
Peptide name
Cerebral cavernous malformations 2 protein

Ligandability

Cysteine 210 of Cerebral cavernous malformations 2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 211 of Cerebral cavernous malformations 2 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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