ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein fuzzy homolog

Intermolecular
Cysteine 838 of Protein inturned and cysteine 365
Intramolecular
Cysteine 151 and cysteine 309
Cysteine 154 and cysteine 309
Cysteine 151 and cysteine 154
A redox-regulated disulphide may form between cysteine 838 of Protein inturned and cysteine 365 of Protein fuzzy homolog. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
7q3d
Structure name
structure of the human cplane complex
Structure deposition date
2021-10-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
96
Peptide A name
Protein inturned
Peptide B name
Protein fuzzy homolog
Peptide A accession
Q9ULD6
Peptide B accession
Q9BT04
Peptide A residue number
838
Peptide B residue number
365

Ligandability

Cysteine 838 of Protein inturned

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 365 of Protein fuzzy homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein fuzzy homolog between cysteines 151 and 309. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7q3d
Structure name
structure of the human cplane complex
Structure deposition date
2021-10-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
83
Minimum pKa ?
11
% buried
100
Peptide accession
Q9BT04
Residue number A
151
Residue number B
309
Peptide name
Protein fuzzy homolog

Ligandability

Cysteine 151 of Protein fuzzy homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 309 of Protein fuzzy homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein fuzzy homolog between cysteines 154 and 309. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7q3d
Structure name
structure of the human cplane complex
Structure deposition date
2021-10-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
93
Minimum pKa ?
13
% buried
100
Peptide accession
Q9BT04
Residue number A
154
Residue number B
309
Peptide name
Protein fuzzy homolog

Ligandability

Cysteine 154 of Protein fuzzy homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 309 of Protein fuzzy homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein fuzzy homolog between cysteines 151 and 154. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
7q3d
Structure name
structure of the human cplane complex
Structure deposition date
2021-10-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
90
Minimum pKa ?
11
% buried
100
Peptide accession
Q9BT04
Residue number A
151
Residue number B
154
Peptide name
Protein fuzzy homolog

Ligandability

Cysteine 151 of Protein fuzzy homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 154 of Protein fuzzy homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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