ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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COP9 signalosome complex subunit 4

Intermolecular
Cysteine 378 and cysteine 181 of COP9 signalosome complex subunit 7b
Cysteine 378 and cysteine 181 of COP9 signalosome complex subunit 7a
Cysteine 378 and cysteine 266 of COP9 signalosome complex subunit 6
A redox-regulated disulphide may form between cysteine 378 of COP9 signalosome complex subunit 4 and cysteine 181 of COP9 signalosome complex subunit 7b. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
6r6h
Structure name
structural basis of cullin-2 ring e3 ligase regulation by the cop9 signalosome
Structure deposition date
2019-03-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
13
% buried
100
Peptide A name
COP9 signalosome complex subunit 4
Peptide B name
COP9 signalosome complex subunit 7b
Peptide A accession
Q9BT78
Peptide B accession
Q9H9Q2
Peptide A residue number
378
Peptide B residue number
181

Ligandability

Cysteine 378 of COP9 signalosome complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 181 of COP9 signalosome complex subunit 7b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 378 of COP9 signalosome complex subunit 4 and cysteine 181 of COP9 signalosome complex subunit 7a. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
4d10
Structure name
crystal structure of the cop9 signalosome
Structure deposition date
2014-04-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
13
% buried
98
Peptide A name
COP9 signalosome complex subunit 4
Peptide B name
COP9 signalosome complex subunit 7a
Peptide A accession
Q9BT78
Peptide B accession
Q9UBW8
Peptide A residue number
378
Peptide B residue number
181

Ligandability

Cysteine 378 of COP9 signalosome complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 181 of COP9 signalosome complex subunit 7a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 378 of COP9 signalosome complex subunit 4 and cysteine 266 of COP9 signalosome complex subunit 6. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
6r7h
Structure name
structural basis of cullin-2 ring e3 ligase regulation by the cop9 signalosome
Structure deposition date
2019-03-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
12
% buried
99
Peptide A name
COP9 signalosome complex subunit 4
Peptide B name
COP9 signalosome complex subunit 6
Peptide A accession
Q9BT78
Peptide B accession
Q7L5N1
Peptide A residue number
378
Peptide B residue number
266

Ligandability

Cysteine 378 of COP9 signalosome complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 266 of COP9 signalosome complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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