Dynactin subunit 5
Intermolecular
Cysteine 128 of Dynactin subunit 6 and cysteine 149
Cysteine 129 of Dynactin subunit 6 and cysteine 149
Cysteine 148 of Dynactin subunit 6 and cysteine 149
Cysteine 18 of Dynactin subunit 6 and cysteine 29
Cysteine 128 of Dynactin subunit 6 and cysteine 114
Cysteine 79 of Dynactin subunit 4 and cysteine 149
7z8m U 128 V 149
A redox-regulated disulphide may form between cysteine 128 of Dynactin subunit 6 and cysteine 149 of Dynactin subunit 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
7z8m
Structure name
the pointed end complex of dynactin bound to bicdr1
Structure deposition date
2022-03-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
66
Peptide A name
Dynactin subunit 6
Peptide B name
Dynactin subunit 5
Peptide A accession
D0G6S1
Peptide B accession
A0A286ZK88
Peptide A residue number
128
Peptide B residue number
149
Ligandability
Cysteine 128 of Dynactin subunit 6
Cysteine 149 of Dynactin subunit 5
6zo4 U 129 V 149
A redox-regulated disulphide may form between cysteine 129 of Dynactin subunit 6 and cysteine 149 of Dynactin subunit 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
6zo4
Structure name
the pointed end complex of dynactin bound to bicd2
Structure deposition date
2020-07-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
9
% buried
62
Peptide A name
Dynactin subunit 6
Peptide B name
Dynactin subunit 5
Peptide A accession
D0G6S1
Peptide B accession
A0A286ZK88
Peptide A residue number
129
Peptide B residue number
149
Ligandability
Cysteine 129 of Dynactin subunit 6
Cysteine 149 of Dynactin subunit 5
6znm U 148 V 149
A redox-regulated disulphide may form between cysteine 148 of Dynactin subunit 6 and cysteine 149 of Dynactin subunit 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6znm
Structure name
the pointed end complex of dynactin bound to bicdr1
Structure deposition date
2020-07-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
55
Peptide A name
Dynactin subunit 6
Peptide B name
Dynactin subunit 5
Peptide A accession
D0G6S1
Peptide B accession
A0A286ZK88
Peptide A residue number
148
Peptide B residue number
149
Ligandability
Cysteine 148 of Dynactin subunit 6
Cysteine 149 of Dynactin subunit 5
7z8m U 18 V 29
A redox-regulated disulphide may form between cysteine 18 of Dynactin subunit 6 and cysteine 29 of Dynactin subunit 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7z8m
Structure name
the pointed end complex of dynactin bound to bicdr1
Structure deposition date
2022-03-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
82
Peptide A name
Dynactin subunit 6
Peptide B name
Dynactin subunit 5
Peptide A accession
D0G6S1
Peptide B accession
A0A286ZK88
Peptide A residue number
18
Peptide B residue number
29
Ligandability
Cysteine 18 of Dynactin subunit 6
Cysteine 29 of Dynactin subunit 5
7z8m U 128 V 114
A redox-regulated disulphide may form between cysteine 128 of Dynactin subunit 6 and cysteine 114 of Dynactin subunit 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7z8m
Structure name
the pointed end complex of dynactin bound to bicdr1
Structure deposition date
2022-03-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
10
% buried
75
Peptide A name
Dynactin subunit 6
Peptide B name
Dynactin subunit 5
Peptide A accession
D0G6S1
Peptide B accession
A0A286ZK88
Peptide A residue number
128
Peptide B residue number
114
Ligandability
Cysteine 128 of Dynactin subunit 6
Cysteine 114 of Dynactin subunit 5
7z8m Y 79 V 149
A redox-regulated disulphide may form between cysteine 79 of Dynactin subunit 4 and cysteine 149 of Dynactin subunit 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
7z8m
Structure name
the pointed end complex of dynactin bound to bicdr1
Structure deposition date
2022-03-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
81
Peptide A name
Dynactin subunit 4
Peptide B name
Dynactin subunit 5
Peptide A accession
A0A4X1TB62
Peptide B accession
A0A286ZK88
Peptide A residue number
79
Peptide B residue number
149
Ligandability
Cysteine 79 of Dynactin subunit 4
Cysteine 149 of Dynactin subunit 5
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