ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Protein PAXX

Intramolecular
Cysteine 9 and cysteine 80
Cysteine 9 and cysteine 22 L
Cysteine 24 and cysteine 80
Cysteine 9 and cysteine 24
Cysteine 22 and cysteine 80 L
Cysteine 22 and cysteine 24 L
A redox-regulated disulphide may form within Protein PAXX between cysteines 9 and 80.

Details

Redox score ?
84
PDB code
4wja
Structure name
crystal structure of paxx
Structure deposition date
2014-09-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
4
% buried
57
Peptide accession
Q9BUH6
Residue number A
9
Residue number B
80
Peptide name
Protein PAXX

Ligandability

Cysteine 9 of Protein PAXX

Cysteine 80 of Protein PAXX

A redox-regulated disulphide may form within Protein PAXX between cysteines 9 and 22.

Details

Redox score ?
78
PDB code
4wja
Structure name
crystal structure of paxx
Structure deposition date
2014-09-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
4
% buried
76
Peptide accession
Q9BUH6
Residue number A
9
Residue number B
22
Peptide name
Protein PAXX

Ligandability

Cysteine 9 of Protein PAXX

Cysteine 22 of Protein PAXX

A redox-regulated disulphide may form within Protein PAXX between cysteines 24 and 80. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
3wtf
Structure name
structure of paxx
Structure deposition date
2014-04-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
12
% buried
66
Peptide accession
Q9BUH6
Residue number A
24
Residue number B
80
Peptide name
Protein PAXX

Ligandability

Cysteine 24 of Protein PAXX

Cysteine 80 of Protein PAXX

A redox-regulated disulphide may form within Protein PAXX between cysteines 9 and 24. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3wtf
Structure name
structure of paxx
Structure deposition date
2014-04-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
4
% buried
72
Peptide accession
Q9BUH6
Residue number A
9
Residue number B
24
Peptide name
Protein PAXX

Ligandability

Cysteine 9 of Protein PAXX

Cysteine 24 of Protein PAXX

A redox-regulated disulphide may form within Protein PAXX between cysteines 22 and 80. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
4wja
Structure name
crystal structure of paxx
Structure deposition date
2014-09-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
16
% buried
70
Peptide accession
Q9BUH6
Residue number A
22
Residue number B
80
Peptide name
Protein PAXX

Ligandability

Cysteine 22 of Protein PAXX

Cysteine 80 of Protein PAXX

A redox-regulated disulphide may form within Protein PAXX between cysteines 22 and 24. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
3wtf
Structure name
structure of paxx
Structure deposition date
2014-04-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
84
Peptide accession
Q9BUH6
Residue number A
22
Residue number B
24
Peptide name
Protein PAXX

Ligandability

Cysteine 22 of Protein PAXX

Cysteine 24 of Protein PAXX

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