ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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DNA-directed RNA polymerase III subunit RPC3

Intermolecular
Cysteine 113 of DNA-directed RNA polymerase III subunit RPC1 and cysteine 79
Cysteine 439 and cysteine 287 of DNA-directed RNA polymerase III subunit RPC6
Intramolecular
Cysteine 9 and cysteine 79
A redox-regulated disulphide may form between cysteine 113 of DNA-directed RNA polymerase III subunit RPC1 and cysteine 79 of DNA-directed RNA polymerase III subunit RPC3. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
100
Peptide A name
DNA-directed RNA polymerase III subunit RPC1
Peptide B name
DNA-directed RNA polymerase III subunit RPC3
Peptide A accession
O14802
Peptide B accession
Q9BUI4
Peptide A residue number
113
Peptide B residue number
79

Ligandability

Cysteine 113 of DNA-directed RNA polymerase III subunit RPC1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of DNA-directed RNA polymerase III subunit RPC3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 439 of DNA-directed RNA polymerase III subunit RPC3 and cysteine 287 of DNA-directed RNA polymerase III subunit RPC6. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7fji
Structure name
human pol iii elongation complex
Structure deposition date
2021-08-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
6
% buried
100
Peptide A name
DNA-directed RNA polymerase III subunit RPC3
Peptide B name
DNA-directed RNA polymerase III subunit RPC6
Peptide A accession
Q9BUI4
Peptide B accession
Q9H1D9
Peptide A residue number
439
Peptide B residue number
287

Ligandability

Cysteine 439 of DNA-directed RNA polymerase III subunit RPC3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 287 of DNA-directed RNA polymerase III subunit RPC6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC3 between cysteines 9 and 79.

Details

Redox score ?
75
PDB code
5afq
Structure name
crystal structure of rpc62 - rpc32 beta
Structure deposition date
2015-01-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
8
% buried
66
Peptide accession
Q9BUI4
Residue number A
9
Residue number B
79
Peptide name
DNA-directed RNA polymerase III subunit RPC3

Ligandability

Cysteine 9 of DNA-directed RNA polymerase III subunit RPC3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of DNA-directed RNA polymerase III subunit RPC3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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