ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Telomerase Cajal body protein 1

Intramolecular
Cysteine 230 and cysteine 284
Cysteine 294 and cysteine 312
Cysteine 330 and cysteine 342
Cysteine 463 and cysteine 512
Cysteine 330 and cysteine 374
Cysteine 284 and cysteine 342
Cysteine 284 and cysteine 330
Cysteine 284 and cysteine 294
A redox-regulated disulphide may form within Telomerase Cajal body protein 1 between cysteines 230 and 284. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7trc
Structure name
human telomerase h/aca rnp at 3
Structure deposition date
2022-01-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
83
Minimum pKa ?
10
% buried
100
Peptide accession
Q9BUR4
Residue number A
230
Residue number B
284
Peptide name
Telomerase Cajal body protein 1

Ligandability

Cysteine 230 of Telomerase Cajal body protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 284 of Telomerase Cajal body protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Telomerase Cajal body protein 1 between cysteines 294 and 312. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7v9a
Structure name
biogenesis module of human telomerase holoenzyme
Structure deposition date
2021-08-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
68
Peptide accession
Q9BUR4
Residue number A
294
Residue number B
312
Peptide name
Telomerase Cajal body protein 1

Ligandability

Cysteine 294 of Telomerase Cajal body protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 312 of Telomerase Cajal body protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Telomerase Cajal body protein 1 between cysteines 330 and 342. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
7bgb
Structure name
the h/aca rnp lobe of human telomerase
Structure deposition date
2021-01-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
89
Minimum pKa ?
12
% buried
98
Peptide accession
Q9BUR4
Residue number A
330
Residue number B
342
Peptide name
Telomerase Cajal body protein 1

Ligandability

Cysteine 330 of Telomerase Cajal body protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 342 of Telomerase Cajal body protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Telomerase Cajal body protein 1 between cysteines 463 and 512. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
7v9a
Structure name
biogenesis module of human telomerase holoenzyme
Structure deposition date
2021-08-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
74
Peptide accession
Q9BUR4
Residue number A
463
Residue number B
512
Peptide name
Telomerase Cajal body protein 1

Ligandability

Cysteine 463 of Telomerase Cajal body protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 512 of Telomerase Cajal body protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Telomerase Cajal body protein 1 between cysteines 330 and 374. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
7v9a
Structure name
biogenesis module of human telomerase holoenzyme
Structure deposition date
2021-08-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
100
Peptide accession
Q9BUR4
Residue number A
330
Residue number B
374
Peptide name
Telomerase Cajal body protein 1

Ligandability

Cysteine 330 of Telomerase Cajal body protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 374 of Telomerase Cajal body protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Telomerase Cajal body protein 1 between cysteines 284 and 342. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
7bgb
Structure name
the h/aca rnp lobe of human telomerase
Structure deposition date
2021-01-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
97
Peptide accession
Q9BUR4
Residue number A
284
Residue number B
342
Peptide name
Telomerase Cajal body protein 1

Ligandability

Cysteine 284 of Telomerase Cajal body protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 342 of Telomerase Cajal body protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Telomerase Cajal body protein 1 between cysteines 284 and 330. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
7bgb
Structure name
the h/aca rnp lobe of human telomerase
Structure deposition date
2021-01-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
100
Peptide accession
Q9BUR4
Residue number A
284
Residue number B
330
Peptide name
Telomerase Cajal body protein 1

Ligandability

Cysteine 284 of Telomerase Cajal body protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 330 of Telomerase Cajal body protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Telomerase Cajal body protein 1 between cysteines 284 and 294. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
21
PDB code
7trc
Structure name
human telomerase h/aca rnp at 3
Structure deposition date
2022-01-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
89
Minimum pKa ?
13
% buried
100
Peptide accession
Q9BUR4
Residue number A
284
Residue number B
294
Peptide name
Telomerase Cajal body protein 1

Ligandability

Cysteine 284 of Telomerase Cajal body protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 294 of Telomerase Cajal body protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: