ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Methylthioribose-1-phosphate isomerase

Intramolecular
Cysteine 127 and cysteine 128
Cysteine 56 and cysteine 128
A redox-regulated disulphide may form within Methylthioribose-1-phosphate isomerase between cysteines 127 and 128. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4ldq
Structure name
crystal structure of the mediator of rho dependent invasion
Structure deposition date
2013-06-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
26
Peptide accession
Q9BV20
Residue number A
127
Residue number B
128
Peptide name
Methylthioribose-1-phosphate isomerase

Ligandability

Cysteine 127 of Methylthioribose-1-phosphate isomerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 128 of Methylthioribose-1-phosphate isomerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylthioribose-1-phosphate isomerase between cysteines 56 and 128. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
4ldq
Structure name
crystal structure of the mediator of rho dependent invasion
Structure deposition date
2013-06-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
10
% buried
70
Peptide accession
Q9BV20
Residue number A
56
Residue number B
128
Peptide name
Methylthioribose-1-phosphate isomerase

Ligandability

Cysteine 56 of Methylthioribose-1-phosphate isomerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 128 of Methylthioribose-1-phosphate isomerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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