ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Monoacylglycerol lipase ABHD6

Intramolecular
Cysteine 172 and cysteine 304
Cysteine 172 and cysteine 217
A redox-regulated disulphide may form within Monoacylglycerol lipase ABHD6 between cysteines 172 and 304. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7ots
Structure name
crystal structure of human monoacylglycerol lipase abhd6 in complex with oleic acid and octyl glucoside
Structure deposition date
2021-06-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
13
% buried
87
Peptide accession
Q9BV23
Residue number A
172
Residue number B
304
Peptide name
Monoacylglycerol lipase ABHD6

Ligandability

Cysteine 172 of Monoacylglycerol lipase ABHD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 304 of Monoacylglycerol lipase ABHD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Monoacylglycerol lipase ABHD6 between cysteines 172 and 217. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
24
PDB code
7ots
Structure name
crystal structure of human monoacylglycerol lipase abhd6 in complex with oleic acid and octyl glucoside
Structure deposition date
2021-06-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
100
Peptide accession
Q9BV23
Residue number A
172
Residue number B
217
Peptide name
Monoacylglycerol lipase ABHD6

Ligandability

Cysteine 172 of Monoacylglycerol lipase ABHD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of Monoacylglycerol lipase ABHD6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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