ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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WD repeat-containing protein 18

Intermolecular
Cysteine 151 and cysteine 492 of Proline-, glutamic acid- and leucine-rich protein 1
Cysteine 151 and cysteine 586 of Proline-, glutamic acid- and leucine-rich protein 1
Intramolecular
Cysteine 85 and cysteine 126
Cysteine 10 and cysteine 20
Cysteine 10 and cysteine 274
Cysteine 126 and cysteine 180
A redox-regulated disulphide may form between cysteine 151 of WD repeat-containing protein 18 and cysteine 492 of Proline-, glutamic acid- and leucine-rich protein 1 (151 and 442 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7uwf
Structure name
human rix1 sub-complex scaffold
Structure deposition date
2022-05-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
98
Peptide A name
WD repeat-containing protein 18
Peptide B name
Proline-, glutamic acid- and leucine-rich protein 1
Peptide A accession
Q9BV38
Peptide B accession
C9JFV4
Peptide A residue number
151
Peptide B residue number
492

Ligandability

Cysteine 151 of WD repeat-containing protein 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 492 of Proline-, glutamic acid- and leucine-rich protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 151 of WD repeat-containing protein 18 and cysteine 586 of Proline-, glutamic acid- and leucine-rich protein 1 (151 and 536 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7uwf
Structure name
human rix1 sub-complex scaffold
Structure deposition date
2022-05-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
98
Peptide A name
WD repeat-containing protein 18
Peptide B name
Proline-, glutamic acid- and leucine-rich protein 1
Peptide A accession
Q9BV38
Peptide B accession
C9JFV4
Peptide A residue number
151
Peptide B residue number
586

Ligandability

Cysteine 151 of WD repeat-containing protein 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 586 of Proline-, glutamic acid- and leucine-rich protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 18 between cysteines 85 and 126. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7uwf
Structure name
human rix1 sub-complex scaffold
Structure deposition date
2022-05-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
98
Minimum pKa ?
11
% buried
100
Peptide accession
Q9BV38
Residue number A
85
Residue number B
126
Peptide name
WD repeat-containing protein 18

Ligandability

Cysteine 85 of WD repeat-containing protein 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of WD repeat-containing protein 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 18 between cysteines 10 and 20. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7uwf
Structure name
human rix1 sub-complex scaffold
Structure deposition date
2022-05-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
104
Minimum pKa ?
12
% buried
100
Peptide accession
Q9BV38
Residue number A
10
Residue number B
20
Peptide name
WD repeat-containing protein 18

Ligandability

Cysteine 10 of WD repeat-containing protein 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 20 of WD repeat-containing protein 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 18 between cysteines 10 and 274. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7uwf
Structure name
human rix1 sub-complex scaffold
Structure deposition date
2022-05-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
107
Minimum pKa ?
11
% buried
100
Peptide accession
Q9BV38
Residue number A
10
Residue number B
274
Peptide name
WD repeat-containing protein 18

Ligandability

Cysteine 10 of WD repeat-containing protein 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 274 of WD repeat-containing protein 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 18 between cysteines 126 and 180. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
25
PDB code
7uwf
Structure name
human rix1 sub-complex scaffold
Structure deposition date
2022-05-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
92
Minimum pKa ?
12
% buried
100
Peptide accession
Q9BV38
Residue number A
126
Residue number B
180
Peptide name
WD repeat-containing protein 18

Ligandability

Cysteine 126 of WD repeat-containing protein 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of WD repeat-containing protein 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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