ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ER membrane protein complex subunit 6

Intermolecular
Cysteine 57 of ER membrane protein complex subunit 5 and cysteine 29 L
A redox-regulated disulphide may form between cysteine 57 of ER membrane protein complex subunit 5 and cysteine 29 of ER membrane protein complex subunit 6. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7ado
Structure name
cryo-em structure of human er membrane protein complex in lipid nanodiscs
Structure deposition date
2020-09-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
85
Peptide A name
ER membrane protein complex subunit 5
Peptide B name
ER membrane protein complex subunit 6
Peptide A accession
Q8N4V1
Peptide B accession
Q9BV81
Peptide A residue number
57
Peptide B residue number
29

Ligandability

Cysteine 57 of ER membrane protein complex subunit 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 29 of ER membrane protein complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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