ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Katanin p80 WD40 repeat-containing subunit B1

Intramolecular
Cysteine 559 and cysteine 622
Cysteine 619 and cysteine 622
Cysteine 559 and cysteine 619
A redox-regulated disulphide may form within Katanin p80 WD40 repeat-containing subunit B1 between cysteines 559 and 622.

Details

Redox score ?
70
PDB code
6gzc
Structure name
heterotetrameric katanin p60:p80 complex
Structure deposition date
2018-07-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
8
% buried
84
Peptide accession
Q8BG40
Residue number A
559
Residue number B
622
Peptide name
Katanin p80 WD40 repeat-containing subunit B1

Ligandability

Cysteine 559 of Katanin p80 WD40 repeat-containing subunit B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 622 of Katanin p80 WD40 repeat-containing subunit B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Katanin p80 WD40 repeat-containing subunit B1 between cysteines 619 and 622. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
5nbt
Structure name
apo structure of p60n/p80c katanin
Structure deposition date
2017-03-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
35
Peptide accession
Q8BG40
Residue number A
619
Residue number B
622
Peptide name
Katanin p80 WD40 repeat-containing subunit B1

Ligandability

Cysteine 619 of Katanin p80 WD40 repeat-containing subunit B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 622 of Katanin p80 WD40 repeat-containing subunit B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Katanin p80 WD40 repeat-containing subunit B1 between cysteines 559 and 619. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
5ow5
Structure name
p60p80-camsap complex
Structure deposition date
2017-08-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
56
Peptide accession
Q8BG40
Residue number A
559
Residue number B
619
Peptide name
Katanin p80 WD40 repeat-containing subunit B1

Ligandability

Cysteine 559 of Katanin p80 WD40 repeat-containing subunit B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 619 of Katanin p80 WD40 repeat-containing subunit B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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