ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Target of rapamycin complex subunit LST8

Intramolecular
Cysteine 238 and cysteine 276 L
Cysteine 244 and cysteine 276 L
Cysteine 194 and cysteine 226
Cysteine 238 and cysteine 244 L
Cysteine 226 and cysteine 276
Cysteine 133 and cysteine 135
Cysteine 133 and cysteine 226
Cysteine 135 and cysteine 226
Cysteine 226 and cysteine 238 L
Cysteine 226 and cysteine 244 L
A redox-regulated disulphide may form within Target of rapamycin complex subunit LST8 between cysteines 238 and 276.

Details

Redox score ?
75
PDB code
4jsp
Structure name
structure of mtordeltan-mlst8-atpgammas-mg complex
Structure deposition date
2013-03-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
97
Minimum pKa ?
4
% buried
100
Peptide accession
Q9BVC4
Residue number A
238
Residue number B
276
Peptide name
Target of rapamycin complex subunit LST8

Ligandability

Cysteine 238 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 276 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Target of rapamycin complex subunit LST8 between cysteines 244 and 276.

Details

Redox score ?
74
PDB code
5wby
Structure name
crystal structure of mtor(deltan)-mlst8-pras40(beta-strand) complex
Structure deposition date
2017-06-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
91
Minimum pKa ?
4
% buried
100
Peptide accession
Q9BVC4
Residue number A
244
Residue number B
276
Peptide name
Target of rapamycin complex subunit LST8

Ligandability

Cysteine 244 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 276 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Target of rapamycin complex subunit LST8 between cysteines 194 and 226.

Details

Redox score ?
64
PDB code
4jsn
Structure name
structure of mtordeltan-mlst8 complex
Structure deposition date
2013-03-22
Thiol separation (Å)
5
Half-sphere exposure sum ?
89
Minimum pKa ?
8
% buried
100
Peptide accession
Q9BVC4
Residue number A
194
Residue number B
226
Peptide name
Target of rapamycin complex subunit LST8

Ligandability

Cysteine 194 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Target of rapamycin complex subunit LST8 between cysteines 238 and 244. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
4jsv
Structure name
mtor kinase structure, mechanism and regulation
Structure deposition date
2013-03-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
92
Minimum pKa ?
14
% buried
100
Peptide accession
Q9BVC4
Residue number A
238
Residue number B
244
Peptide name
Target of rapamycin complex subunit LST8

Ligandability

Cysteine 238 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 244 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Target of rapamycin complex subunit LST8 between cysteines 226 and 276. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
4jt5
Structure name
mtordeltan-mlst8-pp242 complex
Structure deposition date
2013-03-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
93
Minimum pKa ?
4
% buried
100
Peptide accession
Q9BVC4
Residue number A
226
Residue number B
276
Peptide name
Target of rapamycin complex subunit LST8

Ligandability

Cysteine 226 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 276 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Target of rapamycin complex subunit LST8 between cysteines 133 and 135. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
4jsn
Structure name
structure of mtordeltan-mlst8 complex
Structure deposition date
2013-03-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
95
Minimum pKa ?
12
% buried
100
Peptide accession
Q9BVC4
Residue number A
133
Residue number B
135
Peptide name
Target of rapamycin complex subunit LST8

Ligandability

Cysteine 133 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 135 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Target of rapamycin complex subunit LST8 between cysteines 133 and 226. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
5wbu
Structure name
crystal structure of mtor(deltan)-mlst8-pras40(alpha-helix & beta- strand) complex
Structure deposition date
2017-06-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
93
Minimum pKa ?
12
% buried
100
Peptide accession
Q9BVC4
Residue number A
133
Residue number B
226
Peptide name
Target of rapamycin complex subunit LST8

Ligandability

Cysteine 133 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Target of rapamycin complex subunit LST8 between cysteines 135 and 226. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
4jt6
Structure name
structure of mtordeltan-mlst8-pi-103 complex
Structure deposition date
2013-03-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
90
Minimum pKa ?
13
% buried
100
Peptide accession
Q9BVC4
Residue number A
135
Residue number B
226
Peptide name
Target of rapamycin complex subunit LST8

Ligandability

Cysteine 135 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Target of rapamycin complex subunit LST8 between cysteines 226 and 238. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
24
PDB code
4jsp
Structure name
structure of mtordeltan-mlst8-atpgammas-mg complex
Structure deposition date
2013-03-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
96
Minimum pKa ?
14
% buried
100
Peptide accession
Q9BVC4
Residue number A
226
Residue number B
238
Peptide name
Target of rapamycin complex subunit LST8

Ligandability

Cysteine 226 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 238 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Target of rapamycin complex subunit LST8 between cysteines 226 and 244. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
7owg
Structure name
human deptor in a complex with mutant human mtorc1 a1459p
Structure deposition date
2021-06-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
90
Minimum pKa ?
14
% buried
100
Peptide accession
Q9BVC4
Residue number A
226
Residue number B
244
Peptide name
Target of rapamycin complex subunit LST8

Ligandability

Cysteine 226 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 244 of Target of rapamycin complex subunit LST8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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