ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Serine/threonine-protein kinase RIO2

Intermolecular
Cysteine 268 and cysteine 268
A redox-regulated disulphide may form between two units of Serine/threonine-protein kinase RIO2 at cysteines 268 and 268. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6hk6
Structure name
human riok2 bound to inhibitor
Structure deposition date
2018-09-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
12
% buried
100
Peptide A name
Serine/threonine-protein kinase RIO2
Peptide B name
Serine/threonine-protein kinase RIO2
Peptide A accession
Q9BVS4
Peptide B accession
Q9BVS4
Peptide A residue number
268
Peptide B residue number
268

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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