ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tubulin polymerization-promoting protein family member 3

Intramolecular
Cysteine 39 and cysteine 42
Cysteine 42 and cysteine 100
A redox-regulated disulphide may form within Tubulin polymerization-promoting protein family member 3 between cysteines 39 and 42 (46 and 49 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
1wlm
Structure name
solution structure of mouse cgi-38 protein
Structure deposition date
2004-06-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
84
Peptide accession
Q9CRB6
Residue number A
39
Residue number B
42
Peptide name
Tubulin polymerization-promoting protein family member 3

Ligandability

Cysteine 39 of Tubulin polymerization-promoting protein family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 42 of Tubulin polymerization-promoting protein family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tubulin polymerization-promoting protein family member 3 between cysteines 42 and 100. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
2jrf
Structure name
solution nmr structure of tubulin polymerization-promoting protein family member 3 from homo sapiens
Structure deposition date
2007-06-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
56
Peptide accession
Q9BW30
Residue number A
42
Residue number B
100
Peptide name
Tubulin polymerization-promoting protein family member 3

Ligandability

Cysteine 42 of Tubulin polymerization-promoting protein family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Tubulin polymerization-promoting protein family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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