a tool for identifying drug-targetable redox-active disulphides

Sodium channel modifier 1

Intramolecular

Cysteine 44 and cysteine 47

A redox-regulated disulphide may form within Sodium channel modifier 1 between cysteines 44 and 47.

Details

Redox score ?

77

PDB code

Structure name

cryo-em structure of the activated human minor spliceosome (minor bact complex)

Structure deposition date

2021-01-14

Thiol separation (Å)

4

Half-sphere exposure sum ?

66

Minimum pK_a ?

8

% buried

46

Peptide accession

Residue number A

44

Residue number B

47

Peptide name

Sodium channel modifier 1

Ligandability

Cysteine 44 of Sodium channel modifier 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 47 of Sodium channel modifier 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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