a tool for identifying drug-targetable redox-active disulphides

Splicing factor 3B subunit 5

Intermolecular

Cysteine 112 of Splicing factor 3B subunit 3 and cysteine 41

A redox-regulated disulphide may form between cysteine 112 of Splicing factor 3B subunit 3 and cysteine 41 of Splicing factor 3B subunit 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

31

PDB code

Structure name

structure of a minimal sf3b core in complex with sudemycin d6 (form ii)

Structure deposition date

2020-12-14

Thiol separation (Å)

10

Half-sphere exposure sum ?

88

Minimum pK_a ?

10

% buried

100

Peptide A name

Splicing factor 3B subunit 3

Peptide B name

Splicing factor 3B subunit 5

Peptide A accession

Peptide B accession

Peptide A residue number

112

Peptide B residue number

41

Ligandability

Cysteine 112 of Splicing factor 3B subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 41 of Splicing factor 3B subunit 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: