ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Kanadaptin

Intramolecular
Cysteine 197 and cysteine 200
Cysteine 189 and cysteine 197
A redox-regulated disulphide may form within Kanadaptin between cysteines 197 and 200.

Details

Redox score ?
66
PDB code
4h87
Structure name
crystal structure of a fha domain of kanadaptin (slc4a1ap) from homo sapiens at 1
Structure deposition date
2012-09-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
50
Minimum pKa ?
10
% buried
22
Peptide accession
Q9BWU0
Residue number A
197
Residue number B
200
Peptide name
Kanadaptin

Ligandability

Cysteine 197 of Kanadaptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of Kanadaptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Kanadaptin between cysteines 189 and 197. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
4h87
Structure name
crystal structure of a fha domain of kanadaptin (slc4a1ap) from homo sapiens at 1
Structure deposition date
2012-09-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
11
% buried
62
Peptide accession
Q9BWU0
Residue number A
189
Residue number B
197
Peptide name
Kanadaptin

Ligandability

Cysteine 189 of Kanadaptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Kanadaptin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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