ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Synaptonemal complex protein 2

Intramolecular
Cysteine 224 and cysteine 261
Cysteine 42 and cysteine 76
Cysteine 13 and cysteine 76
A redox-regulated disulphide may form within Synaptonemal complex protein 2 between cysteines 224 and 261. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
5iwz
Structure name
synaptonemal complex protein
Structure deposition date
2016-03-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
92
Peptide accession
Q9CUU3
Residue number A
224
Residue number B
261
Peptide name
Synaptonemal complex protein 2

Ligandability

Cysteine 224 of Synaptonemal complex protein 2

Cysteine 261 of Synaptonemal complex protein 2

A redox-regulated disulphide may form within Synaptonemal complex protein 2 between cysteines 42 and 76. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
5iwz
Structure name
synaptonemal complex protein
Structure deposition date
2016-03-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
66
Peptide accession
Q9CUU3
Residue number A
42
Residue number B
76
Peptide name
Synaptonemal complex protein 2

Ligandability

Cysteine 42 of Synaptonemal complex protein 2

Cysteine 76 of Synaptonemal complex protein 2

A redox-regulated disulphide may form within Synaptonemal complex protein 2 between cysteines 13 and 76. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5iwz
Structure name
synaptonemal complex protein
Structure deposition date
2016-03-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
58
Peptide accession
Q9CUU3
Residue number A
13
Residue number B
76
Peptide name
Synaptonemal complex protein 2

Ligandability

Cysteine 13 of Synaptonemal complex protein 2

Cysteine 76 of Synaptonemal complex protein 2

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