ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Succinate receptor 1

Intramolecular
Cysteine 7 and cysteine 263
Cysteine 91 and cysteine 168
A redox-regulated disulphide may form within Succinate receptor 1 between cysteines 7 and 263.

Details

Redox score ?
89
PDB code
6ibb
Structure name
crystal structure of the rat isoform of the succinate receptor sucnr1 (gpr91) in complex with a nanobody
Structure deposition date
2018-11-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6IYF9
Residue number A
7
Residue number B
263
Peptide name
Succinate receptor 1

Ligandability

Cysteine 7 of Succinate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 263 of Succinate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Succinate receptor 1 between cysteines 91 and 168.

Details

Redox score ?
85
PDB code
6ibb
Structure name
crystal structure of the rat isoform of the succinate receptor sucnr1 (gpr91) in complex with a nanobody
Structure deposition date
2018-11-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6IYF9
Residue number A
91
Residue number B
168
Peptide name
Succinate receptor 1

Ligandability

Cysteine 91 of Succinate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 168 of Succinate receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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