ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ion channel TACAN

Intermolecular
Cysteine 12 and cysteine 68
Cysteine 173 and cysteine 173
A redox-regulated disulphide may form between two units of Ion channel TACAN at cysteines 12 and 68.

Details

Redox score ?
62
PDB code
7n0l
Structure name
cryo-em structure of tacan in the h196a h197a mutant form (tmem120a)
Structure deposition date
2021-05-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
5
Peptide A name
Ion channel TACAN
Peptide B name
Ion channel TACAN
Peptide A accession
Q8C1E7
Peptide B accession
Q8C1E7
Peptide A residue number
12
Peptide B residue number
68

Ligandability

Cysteine 12 of Ion channel TACAN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 68 of Ion channel TACAN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Ion channel TACAN at cysteines 173 and 173. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7n0k
Structure name
cryo-em structure of tacan in the apo form (tmem120a)
Structure deposition date
2021-05-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
80
Peptide A name
Ion channel TACAN
Peptide B name
Ion channel TACAN
Peptide A accession
Q8C1E7
Peptide B accession
Q8C1E7
Peptide A residue number
173
Peptide B residue number
173

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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