ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Queuine tRNA-ribosyltransferase catalytic subunit 1

Intramolecular
Cysteine 317 and cysteine 319
Cysteine 319 and cysteine 322
Cysteine 270 and cysteine 275
Cysteine 317 and cysteine 322
Cysteine 67 and cysteine 70
A redox-regulated disulphide may form within Queuine tRNA-ribosyltransferase catalytic subunit 1 between cysteines 317 and 319.

Details

Redox score ?
78
PDB code
7nq4
Structure name
human trna guanine transglycosylase (tgt), rna-bound covalent intermediate
Structure deposition date
2021-03-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
nan
Peptide accession
Q9BXR0
Residue number A
317
Residue number B
319
Peptide name
Queuine tRNA-ribosyltransferase catalytic subunit 1

Ligandability

Cysteine 317 of Queuine tRNA-ribosyltransferase catalytic subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 319 of Queuine tRNA-ribosyltransferase catalytic subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Queuine tRNA-ribosyltransferase catalytic subunit 1 between cysteines 319 and 322.

Details

Redox score ?
74
PDB code
6h45
Structure name
crystal structure of the human tgt catalytic subunit qtrt1 in complex with queuine
Structure deposition date
2018-07-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
59
Peptide accession
Q9BXR0
Residue number A
319
Residue number B
322
Peptide name
Queuine tRNA-ribosyltransferase catalytic subunit 1

Ligandability

Cysteine 319 of Queuine tRNA-ribosyltransferase catalytic subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 322 of Queuine tRNA-ribosyltransferase catalytic subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Queuine tRNA-ribosyltransferase catalytic subunit 1 between cysteines 270 and 275.

Details

Redox score ?
61
PDB code
6h62
Structure name
qtrt1, the catalytic subunit of murine trna-guanine transglycosylase
Structure deposition date
2018-07-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
92
Minimum pKa ?
9
% buried
100
Peptide accession
Q9JMA2
Residue number A
270
Residue number B
275
Peptide name
Queuine tRNA-ribosyltransferase catalytic subunit 1

Ligandability

Cysteine 270 of Queuine tRNA-ribosyltransferase catalytic subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 275 of Queuine tRNA-ribosyltransferase catalytic subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Queuine tRNA-ribosyltransferase catalytic subunit 1 between cysteines 317 and 322. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
7nq4
Structure name
human trna guanine transglycosylase (tgt), rna-bound covalent intermediate
Structure deposition date
2021-03-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
18
% buried
nan
Peptide accession
Q9BXR0
Residue number A
317
Residue number B
322
Peptide name
Queuine tRNA-ribosyltransferase catalytic subunit 1

Ligandability

Cysteine 317 of Queuine tRNA-ribosyltransferase catalytic subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 322 of Queuine tRNA-ribosyltransferase catalytic subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Queuine tRNA-ribosyltransferase catalytic subunit 1 between cysteines 67 and 70. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7nq4
Structure name
human trna guanine transglycosylase (tgt), rna-bound covalent intermediate
Structure deposition date
2021-03-01
Thiol separation (Å)
5
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
100
Peptide accession
Q9BXR0
Residue number A
67
Residue number B
70
Peptide name
Queuine tRNA-ribosyltransferase catalytic subunit 1

Ligandability

Cysteine 67 of Queuine tRNA-ribosyltransferase catalytic subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 70 of Queuine tRNA-ribosyltransferase catalytic subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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